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Lena Serghides's blog

PPAR-gamma agonists for the treatment of cerebral malaria - tweaking the host response to save brains

April 7, 2011 - 14:48 -- Lena Serghides

Even when treated with the best anti-malaria drugs 1 in 5 children with cerebral malaria will die, and of the survivors 1 in 4 will be left with long-term learning and memory impairment. This is because the host response to the infection plays as much a role in contributing to the development of cerebral malaria as does the parasite itself. Although conventional therapies for malaria can be very effective at eliminating the parasite, they do little to modulate the host response.

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