Once a scientific paper is published online and you can download a pdf of it, this addictive and magnificent feeling gets on to you. This is the fruit of all the hard work: first to get the funding to undertake the research, then the hard work to actually perform all the research, then the hard work to write up the manuscript, then the submission, the reviews, the rebuttal, and eventually acceptance followed by proof reading and then publication. The route from thinking up research to publishing about it is long, tedious, and really hard work. But why don't we ever talk about this route? Why do we publish our papers but don't tell our peers more about how we got there? The fun parts, the sweat and tears, or even the fights? This week we published an article in the Proceedings of the National Academy of Sciences USA (PNAS; attached below). And here's the story you don't know when you read the paper...
I invite you to help me imagine a solid and realistic approach to malaria control in Africa, rather than continuing our criticism of the current poorly focussed and unsustainable attempts by WHO, RBM and the US PMI. I think we need a permanent Institute where African malaria people can develop, implement and expand anti-malarial measures. Because the current emphasis on drugs, biocides and bednets is inherently unsustainable, let us take a more sensible and rational approach which utilizes ecological changes.
Bilharzia, schistosomiasis, snail fever, is a disease caused by parasitic worms of the Schistosoma type. It may infect the urinary tract or the intestines. Signs and symptoms may include abdominal pain, diarrhea, bloody stool, or blood in the urine. In those who have been infected for a long time, liver damage, kidney failure, infertility, or bladder cancer may occur. Schistosomiasis affects almost 210 million people worldwide, and an estimated 200,000 people die from it a year,
A team of medical doctors and traditional healers in the Eastern part of the DR Congo just completed the first part of clinical trials studying the efficacy of Artemisia annua against gametocytes. The trials were following a protocol based on the procedures recommended by WHO and are coordinated with a team of medical doctors from France.
Polyphenols are a large group of antioxidants naturally known for their protective effect against oxygen metabolites, acting as free radical scavengers. In contrast to the beneficial effects it has recently been reported that some polyphenols may promote oxidative damage. These harmful effects are suspected to result from a pro-oxidant action.
Although resistance is increasing at an exponential rate, synthetic pyrethroids remain the only recommended insecticides for mosquito nets. One may wonder what the reasons behind this monopoly are : incompetence or business ?
After some important research work had been done some 30 years ago on amino acids, the impact these molecules might have on a vast array of diseases has been neglected. But there is increasing evidence that the amino acid proline plays an important role in the virulence mechanism of human and mammalian pathogens.
BBC NEWS | Health, 24 July 2015
By: Fergus Walsh, Medical correspondent
Introducing rapid diagnostic tests in Ugandan drug shops improves treatment of malaria patients
Using malaria rapid diagnostic tests (RDT) in registered drug shops in a highly endemic region in Uganda substantially reduced overdiagnosis of malaria, improving the use of valuable malaria drugs, according to a new study published in PLOS ONE.
As most of the people suffering from malaria are living in French speaking countries we post also a French version
Les plantes de la grande famille des armoises sont utilisées comme herbes médicinales depuis des millénaires dans toutes les régions du monde.
L’Artemisia annua est venue sous les feux de la rampe lors de la guerre du Vietnam.
The large family of Artemisia plants have been used as herbal medicine for millenniums in all regions of the world.
Help us to win the Social Media 'Malaria Heroes' Award 2015
More than four years after the publication of the Malaria Eradication Research Agenda (malERA), which identified knowledge gaps and tools that will be needed to eradicate malaria, the Malaria Eradication Scientific Alliance (MESA) is leading a consultative process to assess the progress made, examine current hypotheses and identify priority research areas in the next 5-10 years.
Amino-acids in Artemisia annua have barely been studied. The analytical data published by EA Brisibe and J Ferreira date back to 2009 (Food Chemistry, 2009, 115, 1240-1246). Their role in malaria infections has been ignored, except for a study published in Japan (DT Uyen et al., Biol Pharm Bull. 2008, 31, 1483-1488). To gain insight into the mechanism of malarial haemozoin formation, they examined the effects of amino acids on beta hematin formation in vitro. Surprisingly some of these amino acids like arginine, histidine, lysine showed a significant inhibition.
Candidate vaccines based on injectable Plasmodium falciparum (Pf) sporozoites (SPZ), are being developed and tested. These include PfSPZ Vaccine, in which the PfSPZ are attenuated by irradiation; PfSPZ-CVac, in which fully infectious PfSPZ, PfSPZ Challenge, are attenuated in vivo by an anti-malarial drug, to allow only liver stage parasites to grow, and PfSPZ-GA1, in which the PfSPZ are attenuated by gene deletions.
Luteolin (3′,4′,5′,7′-tetrahydroxyflavone) is a widespread flavonoid aglycon structurally related to quercetin. The ethnobotanical use of this flavone includes applications in the treatment of cough, diarrhea, dysentery, diabetes, cancer and malaria.
We have shown a talk by Margaret Heffernan before on the MalariaWorld platform. And again, in a talk she gave in May this year at TEDWomen 2015, she hits the nail on the head, also for us malariologists. That's why we show her talk here...
Imagine your research lab, or your University department, think about your professor and colleagues and the way you work with them. Think about the pressures and frictions that are there when it gets to doing research, to publishing (authorships!), and once you have done that, watch this video. We hope you will feel inspired afterwards!
There is great news for the MalariaWorld community, and particularly for the team that has worked for the last six years to provide you all, every week of the year, with the latest information on malaria. Somebody (thank you, whoever you are) nominated one of the MalariaWorld Founders (me) for the 2015 Social Media Awards 'Malaria Heroes'. I do not consider this as a personal nomination, but as a nomination for the entire MalariaWorld team. Many of our >8600 members know me, but there are people behind the scene that make this work what it is. We have Patrick Sampao, Kabogo Ndegwa, and Stella Chege in the Nairobi office of MalariaWorld. They perform all the searches and collate it in such way that you receive it nicely on Friday morning when you open your email. They are our 'Silent Malaria Heroes', and have been so for six full years already. Then there are volunteers working for the Dutch Malaria Foundation that manage subscriptions (Monika Bongers) and extend the reach of our communication through social media outlets. With a Facebook account and three Twitter accounts, we're busy. Busy to get that vital piece of information out to you. And now we have been nominated...
Moringa oleifera is called the „miracle tree“, and has a strong reputation for curing many diseases, but it is impossible to find any peer reviewed paper on PubMed which describes antimarial properties for this plant. This probably does not exclude the presence in the plant of a few molecules which could demonstrate antiplasmodial properties in vitro.
Dry leaves of the plant do not inhibit beta-hematin (G Mergeai, personal communication) in the assay which is often used to screen for antimalarials.
On October 23 , 2014 WHO issued a recommandation (www.who.int/elena/titles/zinc_diarrhoea) stating that mothers, other caregivers and health workers should provide children with 20 mg per day of zinc supplementation for 10-14 days (10 mg per day for infants under the age of six months).
Mosquitoes are progressively becoming resistant to industrial repellents and insecticides. This is the case for pyrethroids used on bednets.
Most of these products are expensive and African households cannot afford their purchase.
Plants, their extracts and their essential oils have been used during centuries to fight aggressive mosquitoes responsible for malaria, dengue, sleeping sickness but also insects acting as vectors for many other diseases.
Most research work on Artemisia annua has ignored saponins and polysaccharides because these are only soluble in water and in the search of the golden fleece or the exceptional antimalarial molecule most extracts are obtained with organic solvents.
Saponins are found in many plants, often in desert plants and are also present in some marine organisms. Most medicinal plants are rich in saponins, which to a large extent are responsible for their bitterness. In fact saponins protect plants from phytopathogenic microorganisms, phytophagous mammalian and insects.
Re-imagining malaria – a platform for essential reflections to widen horizons in malaria control
Edited by: Dr. Julian Eckl, Dr. Susanna Hausmann Muela
Poor quality and fake anti-malaria medicines can be deadly and cause a big problem in the fight against malaria. Previous reports indicated that up to 1/3 of the antimalarial medicines could be fake. A recent study of anti-malarials in Tanzania and Cambodia showed no evidence of fake medicines in these countries. So could it be that the problem of fake drugs in Africa is less than expected?