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Malaria suppression improves economic productivity

June 6, 2016 - 11:32 -- William Jobin

In a recent Comment - Does malaria cause poverty or vice-versa? Patrick Sampao explored the relation between malaria and poverty. In accord with his opinions, and in agreement with our dear friend Anton Alexander, I posted three comments, based on statistical analyses of the impact of the US Presidential Malaria Initiative. The comments show us some really Good News about suppressing malaria, especially in Africa where the data is robust. Please take a look at the comments. It is kind of heavy reading but I assure you, it is worthwhile.

New report from WHO on malaria elimination

June 5, 2016 - 21:09 -- Bart G.J. Knols
This report, presented on World Malaria Day 2016, focuses on the third goal from the Global Technical Strategy for malaria: 2016-2030: malaria elimination. It offers a brief analysis of recent country-level progress towards elimination and spotlights countries that are poised to reach the finish line in the next  five years.
A number of countries have had remarkable success in controlling malaria, and these achievements are hard-won. But in many respects, the hardest work is yet to come. This WHO report highlights the considerable challenges countries will face in their e orts to drive down malaria cases to zero and to prevent resurgences of this deadly disease.

Why are Artemisia plants prophylactic? The herbicidal hypothesis.

May 29, 2016 - 13:07 -- Pierre Lutgen

Ἓν οἶδα ὅτι οὐδὲν οἶδα


Our association IFBV-BELHERB has received numerous anecdotic reports on the prophylactic effects of Artemisia plants. This effect has been documented in scientific papers. Patrick Ogwang from Uganda (Ogwang PE, et al. Trop J Pharm Res. 2012;11:445–53) showed that an infusion of Artemisia annua consumed once weekly reduced the risk of Plasmodium falciparum episodes due to a yet unidentified constituent.

A case of treatment failure and malarone poisoning

May 20, 2016 - 16:00 -- Pierre Lutgen

Reported by Dr Patrice Bouygues, Paris.

A young French traveller was infected by Plasmodium falciparum during a two week stay in Tchad in 2013. He had been treated prophylactilly and therapeutically with Malarone. After his return home he continued suffering from headaches, high fever surges, rachialgies, cardiac troubles... Several medical services were consulted. Despite the absence of noticeable parasites in blood smears, doctors prescribed a more or less continuous malarone and tardyferon treatment.

Pentacyclic triterpenes in antimalarial plants, a new paradigm

May 8, 2016 - 07:48 -- Pierre Lutgen

Many plants have antiplasmodial properties but nobody really knows why some do and others do not. We have paid most of our attention to artemisinin and derivatives, to flavonoids and antioxidants, swamped and blinded by thousands of papers on these molecules, billions invested and earned in ACTs, the prohibition of clinical trials with Artemisia annua by WHO-Geneva, the Vatican of malaria, and the colonial ITG-Antwerp. And we have forgotten that there are other molecules in Artemisia which may play an equivalent or stronger role.


New from MESA: 5 experts pick a recent eye-opening paper on malaria

May 6, 2016 - 07:09 -- MESA Alliance


As a scientific worker we need innovation spirit to find new things” commented Tu Youyou in a telephone interview following the announcement of the 2015 Nobel Prize in Physiology or Medicine.[1] The Chinese scientist was awarded the Prize for her discovery of artemisinin in the 1970s, now a life-saving antimalarial drug. Leading a small team of researchers, she was the first to isolate the active ingredient from the Artemisia plant, using ether to extract it.

ACT Consortium: Free resources to develop malaria diagnosis and treatment interventions

May 6, 2016 - 06:32 -- Ingeborg van Schayk


ACT Consortium launches free resources for malaria community 

On World Malaria Day, ACT Consortium researchers launched five resources to help guide those working in malaria endemic countries.

25 April 2016 - WHO Report Eliminating Malaria

April 29, 2016 - 10:09 -- Ingeborg van Schayk

In May 2015, the World Health Assembly endorsed a new Global Technical Strategy for Malaria. The strategy includes ambitious goals for malaria control and elimination in the next 15-year period. A key target: eliminating malaria in at least 10 countries by 2020. According to a new analysis from WHO, this goal can be achieved – and surpassed.

Video: What will it take to end malaria? Bill Gates and George Osborne discuss

April 29, 2016 - 10:05 -- Ingeborg van Schayk

This video was released on World Malaria day 2016. In January 2016, Bill Gates and UK Chancellor of the Exchequer George Osborne launched a new fund that will mobilize some of Britain’s best scientists to fight malaria. They met in Liverpool to talk about what it will take to end malaria for good.


Pulmonary administration of Artemisia afra against tuberculosis

April 29, 2016 - 09:34 -- Pierre Lutgen

Many constituents of medicinal herbs have a low bioavailabity, especially if administered orally. They do not pass the intestinal barrier. This is particularly the case for essential oils. A study (Ryuichi Fujisaki et al., of the in vitro and in vivo antiplasmodial activity of 47 essential oils showed that several have strong in vitro antiplasmodial activities, with IC50 values < 1.0 µg/ml. But notably these oils showed no efficacy when administered orally.

Partnership between Tropicare and Dutch Malaria Foundation announced

April 24, 2016 - 15:05 -- Ingeborg van Schayk

ALMERE, 22 March 2016. Today, two Dutch organisations that share a passion for making malaria history joined forces through the creation of a unique partnership. Tropicare, which runs the Care Plus® brand, encourages travellers, tourists, and day trippers to travel as healthy as possible. It has an extensive offering of products that are specifically designed for travellers to protect themselves against mosquito bites and malaria, such as repellents, bednets, and impregnated clothing.

Malaria, folates and PABA

March 30, 2016 - 17:38 -- Pierre Lutgen

Folates combine three molecules : pretidine & para-aminobenzoic acid (PABA) & glutamate. They were discovered around 1940 and first isolated from spinach leaves. The term folate is derived from the latin word folium.

The malaria parasite has a unique feature of being able to salvage exogenous folate derivatives and/or synthesize them de novo. Due to its high rate of replication, the parasite has a high demand for folates. Folate metabolism is the target of several antimalarials.

Blog: Revolutionary new malaria test could save lives by being faster, more accurate and easier to use

March 18, 2016 - 08:00 -- Ingeborg van Schayk
This is an expert blog by Prof Daouda Ndiaye
A new method of testing for malaria that will put less strain on lab technicians and provide more accurate results at the same time could be a watershed moment in the battle against a disease that is one of the top three killers of children worldwide.

When will permanent methods be added by PMI?

March 11, 2016 - 14:43 -- William Jobin

In a recent analysis of the US Presidential Malaria Initiative (PMI) by Richard Oxborough, it was pointed out that indoor spraying is being reduced and even abandoned as a control measure because of resistance to the cheaper insecticides. In Angola, they have completely abandoned indoor spraying as a method. The newer insecticides are too expensive.

It is alarming that now the only effective control method available is drugs. What will happen when drug resistance spreads? Is PMI prepared for this?

Artemisia plants, prophylaxis and gut microbiota

March 8, 2016 - 08:11 -- Pierre Lutgen

The human gut microbiota has become the subject of extensive research in recent years and our knowledge of the resident species and their potential functional capacity is rapidly growing. Our gut harbours a complex community of over 100 trillion microbial cells which influence human physiology, metabolism, nutrition and immune function while disruption to the gut microbiota has been linked with many diseases.

Are Artemisias the only plants containing arachidonic acid?

February 26, 2016 - 18:24 -- Pierre Lutgen


Arachidonic acid (AA or ARA) is an extremely important fatty acid involved in cell regulation. It is a polyunsaturated fatty acid (20:4n6) covalently bound in esterified form in membrane phospholipids of most body cells. Following irritation or injury, arachidonic acid is released and oxygenated by enzyme systems leading to the formation of an important group of inflammatory mediators, to the prostaglandins products (PGE₂) by the cyclooxygenase enzyme.

Antiretrovirals and antimalarials (FRENCH VERSION). Un mélange fatal!

February 19, 2016 - 08:57 -- Pierre Lutgen

Lors de la conférence du 19 mai 2014 à l’Université du Nebraska qui portait sur le SIDA, F.A. Fehintola montrait que la nevapirine prescrite simultanément avec l’artemether-lumefantrine (Coartem) réduisait de 70% la concentration du principe actif lumefantrine dans le sang infecté.

Ceci ne fait que confirmer des résultats obtenus en Afrique du Sud (T Kredo , Antimicrob Agents Chemother. 2011 Dec; 55(12):5616-23). L’artemether et la nevapirine sont métabolisés par le cytochrome P450 3A4 induit par la nevapirine.

Artesunate causes recrudescence, Artemisia however kills gametocytes

February 16, 2016 - 11:03 -- Pierre Lutgen

A paper from Mali published last week is alarming (AA Djimbe et al., Parasite, 2016. 23, 3). Artesunate does not clear mature gametocytes during oral artesunate treatment and does not prevent the appearance of new gametocytes. This confirms to a large extent the randomized, double blind, large scale clinical trials of Munyanga and Idumbo in Maniema-Congo end of last year (see

Artemisia defeats schistosomiasis

February 9, 2016 - 12:53 -- Pierre Lutgen

In parallel with the clinical trials run by a team of medical doctors in the province of Maniema on the efficiency of Artemisia annua and Artemisia afra against malaria, (see Breaking News Jan.5 on they have completed another large scale randomized, double blind trial against schistosomiasis, Artemisia vs Praziquantel.


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