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Viruses, Malaria, Platelets and Artemisia

May 23, 2020 - 10:12 -- Pierre Lutgen

 

In my previous comments on www.malariaworld.org I alerted to the possibility that the widespread malaria infections in sub-Saharan Africa might provide a protection against the Covid virus. Trying to find an explanation for this observation might be important.

Last week at MalariaWorld: Malaria can’t afford to lose resources to coronavirus and more...

May 21, 2020 - 19:25 -- Ingeborg van Schayk

 


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Podcast: Serological Tests for P. vivax Malaria Could Reduce Disease Transmission by 69%

May 15, 2020 - 19:35 -- Malaria Minute

Malaria Minute, 15 May 2020

Antibody tests for P. vivax malaria could reduce disease prevalence by up to 69% and scientists develop a sex-distorter gene drive that eliminates populations of mosquitoes in the lab.

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World Health Organization: Malaria eradication: benefits, future scenarios & feasibility

May 13, 2020 - 13:53 -- Malaria World

Report of the Strategic Advisory Group on Malaria Eradication

After a 3-year study of trends and future projects, WHO’s Strategic Advisory Group on Malaria Eradication has released a detailed report of its key findings and recommendations. The report builds on an executive summary published in August 2019. Members of the advisory group highlight 6 areas in the report that would underpin a successful malaria eradication effort:

1. reinforcing the Global technical strategy for malaria 2016-2030;
2. research & development for new tools;
3. access to affordable, high quality, people-centered health care and services;
4. adequate and sustained financing;
5. strengthened surveillance and response; and
6. engaging communities.

Community-based health care in the context of the COVID-19 pandemic

May 13, 2020 - 13:14 -- Malaria World

Community-based health care, including outreach and campaigns, in the context of the COVID-19 pandemic

Community-based health care is an essential part of primary care at all times; in the context of the COVID-19 pandemic, the distinct capacity of trusted community members for social engagement and delivering care where it is needed is ever more critical. This joint WHO, UNICEF and IFRC guidance addresses the role of community-based health care in the pandemic context. It includes practical recommendations for decision makers to help keep communities and health workers safe, to sustain essential services at the community level, and to ensure an effective response to COVID-19. Using this comprehensive and coordinated approach will help countries strengthen the resilience of community-based health services throughout the pandemic, into early recovery and beyond. Read more

Malaria still kills 1,100 a day. It can’t afford to lose resources to coronavirus

May 2, 2020 - 16:45 -- Fredros Okumu

As we mark this year’s World Malaria Day, we must emphasize the need for stronger health systems and sustained investments to more aggressively tackle malaria despite the coronavirus pandemic. Since the start of this year, malaria has killed about 100 times more people in Africa than COVID19. And today, there will be another 1100 malaria deaths, tomorrow the same number. If not addressed, there will be many more people indirectly killed by other diseases such as malaria, HIV and tuberculosis than by the outbreak itself.

Podcast: Combined Use of MDA and IRS Most Effective Way to Prevent Malaria Transmission

May 1, 2020 - 15:23 -- Malaria Minute

Malaria Minute, 1 May 2020

The combined use of mass drug administration and indoor residual spraying is the most effective way to reduce malaria prevalence in low malaria-endemic settings, and antibodies against PfGARP kill malaria-infected cells by inducing cell death.

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Keystone Symposia Interview: Malaria Challenges in the COVID-19 Era

April 28, 2020 - 15:36 -- Malaria World

Watch this exclusive interview & presentation by Dr. Pedro Alonso, WHO Global Malaria Programme Director, on how to tackle both of these global threats simultaneously. Brought to you by Keystone Symposia:

https://bit.ly/VKScovidmalaria

New from MESA: ASTMH 2019 Recap in the MESA Resouce Hub: How modeling has been used to provide technical support to national malaria control programs

April 28, 2020 - 14:35 -- MESA Alliance

Watch the presentations from this symposium, in which different experts talked about the importance of malaria modeling to understand the epidemiology of the disease and to help in the decision-making process by testing different scenarios.

Podcast: Gene Drive Outcomes Not Determined by Genetic Variation

April 24, 2020 - 14:30 -- Malaria Minute

Malaria Minute, 24 April 2020

Genetic variation would seem to have little impact on the success of gene drive interventions due to conserved Cas9 target sites in populations of Anopheles mosquitoes.

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Printed bed nets to protect underprivileged families in Uganda against malaria

April 23, 2020 - 16:57 -- Malaria World

In honour of World Malaria Day 2020

Care Plus® has donated 2000 impregnated printed bed nets to protect children in Uganda, one of the countries with the heaviest malaria burden in Africa. And this is just the start of the Buy One, Give One Program: for every Care Plus® impregnated net that is being sold, one free net is donated to people in need. It is one of the contributions that Care Plus® makes to the fight against malaria.

World Malaria Day 2020 - Zero malaria starts with me

April 23, 2020 - 14:04 -- Malaria World


 

In the lead-up to this year’s World Malaria Day, countries across the globe are in the throes of responding to the COVID-19 pandemic. While cases of the novel coronavirus in malaria-affected countries currently represent only a small proportion of the global total, the situation is evolving rapidly. WHO underlines the critical importance of sustaining efforts to prevent, detect and treat malaria, using best practices to protect health workers and communities from COVID-19 infection.

World Health Organization: Tailoring malaria interventions in the COVID-19 response

April 22, 2020 - 15:34 -- Malaria World

During the COVID-19 pandemic, the malaria community must remain committed to supporting the prevention of malaria infection, illness and death through preventive and case management services, while maintaining a safe environment for patients, clients and staff. Deaths due to malaria and its comorbidities (anaemia, undernutrition, etc.) must continue to be prevented.

This document provides overarching principles as well as specific technical guidance for malaria interventions, including prevention of infection and disease, care and treatment of cases, testing, clinical services, supply chain and laboratory activities, during this time of the evolving COVID-19 pandemic. This document will be updated as the situation changes.

 

 

 

Don't forget to register for the free ePanel discussion “The Malaria Endgame” Free Virtual Event from Keystone Symposia!

April 16, 2020 - 12:52 -- Malaria World

REGISTER NOW for the April 22, 2020 free ePanel discussion featuring field leaders as they discuss the latest advances and innovative approaches to eliminate malaria—from vaccines, to genetically modified mosquitos and more. Discover new insights into disease biology, co-infections, epidemiology, and public health strategies in this virtual event, integrating basic research, medical advances and translational applications... Read more

Obituary: 'Have no Fear Wilkes is here' - Tony Wilkes (1933-2020)

April 15, 2020 - 08:48 -- Ingeborg van Schayk

Mr Tony Wilkes MIBiol was a field entomologist at the East African Malaria Institute in Amani, Tanzania (then called Tanganyika), from 1958 to 1964 working on the main vectors of malaria in Africa. Returning to the UK in 1965 he worked on the behaviour of mosquitoes at the University of Sussex’s School of Biology, moving to Imperial College, Silwood Park, Ascot, in 1980, working on sand fly biology and behaviour, and in 1987 to the London School of Hygiene and Tropical Medicine working on mosquito biology and control until his retirement in 1995. The obituary below was contributed by Dr. Derek Charlwood.

Podcast: Enhancing Fc-Dependent Effector Functions Could Improve Protective Efficacy of RTS,S

April 10, 2020 - 10:31 -- Malaria Minute

Malaria Minute, 10 April 2020

Enhancing antibody induction may improve the protective efficacy of RTS,S and researchers find that more gametocytes are produced when human infection is initiated by blood-stage parasites compared to mosquito bite.

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Message from Director Global Malaria Programme about Malaria & COVID-19

April 2, 2020 - 10:54 -- Malaria World

Dear friends and partners,

In addition to our WHO web statement (in English and French) urging countries to ensure the continuity of malaria services, we have developed an online Q&A in: English; French; Spanish; Arabic; Chinese; and Russian.

WHO technical brief for countries preparing malaria funding requests for the Global Fund (2020 - 2022)

March 31, 2020 - 13:51 -- Malaria World

 

After many years of great progress in our fight against malaria, our trajectory is plateauing and the world will not achieve the 2020 malaria targets for morbidity and mortality reduction. With over 400 000 deaths and in excess of 200 million malaria cases each year, we must urgently evolve our approach if we are to realize the full potential of current tools and the available resources and get back on track.

The country-led “High burden high impact” (HBHI) response, launched in 2018 by WHO and the RBM Partnership to End Malaria, aims to reignite the pace of progress in the global malaria fight and is guided by four key elements.

Podcast: Chloroquine Considered as Potential Treatment for COVID-19

March 27, 2020 - 16:48 -- Malaria Minute

Malaria Minute, 27 March 2020

Scientists evaluate chloroquine as a potential treatment for the coronavirus and, as it continues to spread around the world, a report in The Lancet stresses the need for preparedness in malaria-endemic regions.

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WHO urges countries to ensure the continuity of malaria services in the context of the COVID-19 pandemic

March 25, 2020 - 16:30 -- Malaria World

Safety of front-line health workers a primary concern

The COVID-19 pandemic is testing the resilience of robust health systems around the world. Recognizing the heavy toll that malaria exacts on vulnerable populations in sub-Saharan Africa, as well as the region’s fragile health infrastructure, WHO underlines the critical importance of sustaining efforts to prevent, detect and treat malaria.

New from MESA: ASTMH 2019 Recap in the MESA Resource Hub: Routine Data for Decision-Making: Driving Progress in Malaria Control

March 25, 2020 - 15:22 -- MESA Alliance

Watch the presentations from this symposium, in which experts from three different African countries (Mozambique, Tanzania and Zambia) highlighted innovative initiatives across diverse setting to use routine data for decision-making.

Podcast: PIMMS43 Enables Malaria Parasite to Evade Mosquito Immune System

March 20, 2020 - 17:07 -- Malaria Minute

Malaria Minute, 20 March 2020

A protein called PIMMS43 enables the malaria parasite to evade the mosquito’s immune system and scientists describe a highly conserved protein in the malaria parasite that is essential for the invasion of red blood cells.

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Podcast: Demand for Coffee Has a Direct Link to Malaria Risk

March 14, 2020 - 17:37 -- Malaria Minute

Malaria Minute, 14 March 2020

The global supply chain linked to deforestation leads to an increase in malaria prevalence and scientists identify the mechanism of action of clemastine, an antihistamine that inhibits multiple stages of the malaria parasite’s lifecycle.

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New from MESA: ASTMH 2019 Recap in the MESA Resouce Hub: Learning from experience to optimize chemoprevention strategies for malaria

March 10, 2020 - 16:35 -- MESA Alliance

Watch the presentations from this MESA-organized symposium, which brought together a group of experts to address the latest advances in malaria chemoprevention and discuss the impact and challenges faced when translating and scaling up from the trials to the field.

Podcast: Researchers Target Plasmepsin as Avenue for Potential New Therapies

March 7, 2020 - 17:33 -- Malaria Minute

Malaria Minute, 7 March 2020

Researchers target Plasmepsin proteases as resistance to ACT grows, and the process by which the malaria parasite suppresses the immune system is detailed by scientists.

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Podcast: Scientists Convene for MAM2020 in Australia

February 29, 2020 - 14:26 -- Malaria Minute

Malaria Minute, 28 February 2020

The Molecular Approaches to Malaria Conference takes place in Australia, and a study into the long-term side effects of antimalarials could not identify any sufficient evidence of association between malaria prophylaxis and adverse health effects.

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Artemisia afra completely inhibits transmission of gametocytes

February 27, 2020 - 19:35 -- Pierre Lutgen

Gametocytes are loaded with hemozoin resulting from hemoglobulin consumption. Their voracious need of this food may explain why they hide in the bone marrow where they find a large supply of young red blood cells generated by erythropoiesis. Malaria leads to hemolysis and anemia, often severe, and this triggers and amplifies erythropoiesis.  Over the years it became evident that not only intravenous artesunate often causes hemolysis, but also ACT therapy.

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