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Immunosuppression, ACTs and malaria resistance

July 16, 2013 - 06:39 -- Pierre Lutgen

A paradigm change

It was always believed that resistance is provoked by antimalarial drugs; they cause plasmodium to evolve and become tougher. Consequently it was important to kill the last parasite to avoid recrudescence. But Andrew Read (Conference Evolution, Utah, June 21-25 2013) finds that in a weakened immune system parasites multiply to extremely high densities. This pool of parasites contains a larger number of mutants, upping the chances of some having greater virulence potential.

CLOSED: Job: Technical Officer (Coordinator Emergency Response to Artemisinin Resistance in the GMS Programme) - closing date 17 July.

June 29, 2013 - 11:20 -- MalariaWorld Jobs

Organisation: World Health Organization (WHO); WPRO Regional Office for the Western Pacific (WP/RGO)

Location: Phnom Penh, Cambodia

Deadline: 17 July 2013.

MIM2013: Confirmed Plenary speakers

June 27, 2013 - 21:14 -- MalariaWorld Events
Prof Kelly Chibale (University of Cape Town)

 

Prof Kiaran Kirk (Australia National University)

 

Prof Dominic Kwiatkoski (Oxford University)

 

Dr Abdisalan Noor (KEMRI, Kenya)

 

Prof Arjen Dondorp (Mahidol-Oxford, Thailand)

 

Dr Fatoumata Nafo-Traore (RBM/WHO – Switzerland)

 

Dr Vasee Moorthy (WHO – Switzerland)

    

Prof Alister Craig (Liverpool School of Tropical Medicine)

 

Dr Robert Newman (WHO – Switzerland)

 

Dr Awa Coll-Seck (Minister of Health – Senegal )

Why synthetic artemisinin is a bad idea.

June 21, 2013 - 10:20 -- Irene Teis

WE are astonished that only 50 of the 7917 malaria experts on www.malariaworld.org have an opinion on synthetic artemisinin production and the impact this may have on farmers in poor countries. Somebody sent us yesterday the blog “Why Synthetic Artemisinin Is Still a Bad Idea “ from Jim Thomas of the ETC Group. Hereafter a few excerpts which deserve consideration

The problem of ACTs: counterfeit or unstable ?

June 15, 2013 - 18:23 -- Pierre Lutgen

A recent paper (K van Acker, J Plaizier, Malaria Journal, 2012-11 Suppl.1) confirms the concern raised by previous publications: “Stability of artemisinin derivatives has so far only been partially investigated and it is unclear how much this contributes to the reports of bad quality or substandard antimalarials” One of the conclusions of this study is that” Artesunate and amodiaquine can only be used in a fixed dose combination if they are physically separated”.

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