Learn the latest experimental approaches for generating genetic mutations in human malaria parasites.
Please note: Due to the ongoing Covid-19 pandemic, the 2021 Malaria Experimental Genetics (The Gambia) course will be delivered in a virtual format.
In collaboration with the Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, we are pleased to announce the Malaria Experimental Genetics course.
This laboratory-based Advanced Course will give participants a working knowledge of and practical experience in cutting-edge Plasmodium experimental genetics techniques, from designing gene targeting vectors and creating transgenic parasites to genotyping and phenotyping the strains that result. The goal is to facilitate the participants’ own research careers by exposing them to state-of-the-art experimental approaches, while discussing the advantages and limitations of each approach. The course is targeted to early career malaria scientists who are looking to establish and use Plasmodium transfection technology at their host institutes.
The week-long residential course will cover experimental approaches to generating genetic mutations in the human malaria parasites Plasmodium falciparum and Plasmodium knowlesi. The course is hands-on and attendees will learn how to generate gene targeting constructs, with a particular focus on CRISPR-Cas9 experimental design. Participants will also perform different transfection approaches, undertake practical exercises in genotyping of modified parasites, and both observe and learn advanced molecular phenotyping approaches including drug response assays and flow cytometry. Experimental genetic approaches in other malaria parasites including the rodent malaria model Plasmodium berghei will also be discussed.
Target audience: The course is open to applicants based in Africa and should be postdoctoral scientists, PhD students or clinician scientists/healthcare professionals engaged in, or soon to commence, relevant research.
Application and bursary deadline: 24 June 2021