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T-REX of RBC Genetic Variants to Prevent or Ameliorate Cerebral Malaria

April 19, 2018 - 05:57 -- Philip JAJOSKY

As of April 2018, there are 4 PubMed articles that propose the immediate evaluation of T-REX for the prevention of malaria deaths (under author name "JAJOSKY"). These proposals represent 4 (malaria-specific) cell-therapy variations of the special-donor concept highlighted by the successful (HIV-specific) cell-therapy administered to "the Berlin patient."

Because most malaria deaths involve children, the required red-blood-cell or whole-blood volumes needed for the therapeutic exchange transfusions will generally be small. Fortunately, T-REX is much simpler, safer, and less labor-intensive than using genetic immune-cell variants to treat HIV infection ("the Berlin patient").

Also fortunate, identifying and registering special donors is already a post "Berlin patient" recommendation. So, making the case for celebrating T-REX donors should not be difficult since we have had more than 10-years to consider the life-saving implications for "the Berlin patient" genetic-variant precedent.

We eagerly await evaluation of T-REX in seriously ill malaria patients who are mostly children. Preventing death -- and the agony and neurological sequelae of cerebral malaria -- would be a wonderful legacy for "the Berlin patient," a contemporary medical hero who continues to advocate for the use of special donor cells. Human evolution has blessed us with remarkable genetic variants that can be used to save lives and reduce suffering.



Submitted by Philip JAJOSKY on

Anthony Fauci, the director of the NIH’s National Institute of Allergy and Infectious Diseases Fauci agrees that "the Berlin patients" has been cured. Regarding that therapeutic strategy, he noted that “It’s very nice, and it’s not even surprising” meaning that if you take away someone’s immune system and give him a new one resistant to HIV, it’s logical that he would be cured of AIDS. “But it’s just off the table of practicality.” Fortunately, T-REX is not only simpler than that HIV strategy, T-REX is simpler and safer than performing appendectomies in Burkina Faso to prevent death among patients suffering from parasite-induced appendicitis. So, precedents have already been established which support the evaluation of T-REX: T-REX is simpler and less expensive than life-saving appendectomies in West Africa and elsewhere. "The Berlin patient" has validated the therapeutic concept underlying T-REX, but appendectomies highlight the feasibility and economic value of saving lives via T-REX of RBC genetic cell variants everywhere, including in developing nations.

Philip Jajosky, MD, MPH

Submitted by Philip JAJOSKY on

Regarding time delays for translating new therapies into actual clinical use, these delays can exceed 10-years -- yet another very frustrating "inconvenient truth." If you look at the rate at which children suffer or die from cerebral malaria, the numbers per month are very disturbing.

Philip Jajosky, MD, MPH