New Method under ultrasound for rapid extraction and efficient purification of the antimalarial drug "Artemisinin" from medicinal plants.
Free download from Elsevier available till July 30th : http://authors.elsevier.com/a/1TBDt4p3AWHr29
Ultrasound-assisted extraction (UAE) is widely used for the extraction secondary metabolites such as essential oils, flavonoids and carotenoids. The present study proposes an a rapid extraction system based on ultrasound-horn setup for the extraction of a natural active compound ‘‘artemisinin” from Artemisia annua L. leaves as an alternative to hot maceration technique. Ultrasound leaching improves artemisinin recovery at all temperatures where only ten minutes is required to recover 70% (4.42 mg/) compared to 60 min of conventional hot maceration for the same yield. It is noted that prolonged treatment periods under ultrasound are not adequate to obtain high purity crystals; instead short time of ultrasound leaching at low temperature combined with a purification step is recommended to achieve highest purity of crystals.
For instance, the data reported herein document that crystal purity is enhanced after sequential mixing of extracts with activated charcoal and celite even for samples processed at higher temperatures.
Consequently, ultrasound input could be a key to achieve significant cut in production cost of artemisin in based combination drugs.