MESA Correspondents bring you cutting-edge coverage from the virtual ASTMH 2020 Annual Meeting
Day 3: Tuesday, 17th November 2020
The malaria-related symposiums covered by the MESA Correspondents for the third day of the ASTMH 2020 are:
- Symposium #32: Alan J. Magill Malaria Eradication Symposium - Basic Research in Africa for Sustained Malaria Elimination and Eradication Speakers: Silvia N. Kariuki, Yaw Aniweh, Kathryn J. Wicht and Laurent Dembele.
- Symposium #33: Human Challenge Infections: Learning from Nature in Controlled Settings Speakers: Meta Roestenburg, James S. McCarthy, Melissa C. Kapulu and Anna Durbin.
Silvia N. Kariuki (KEMRI-Wellcome, Kenya) gave a riveting talk titled “Red blood cell tension protects against severe malaria in the blood group variant Dantu”. In their study they aimed to characterize P. falciparum invasion into red blood cells (RBCs) and the RBC membrane structure across genotype groups (Dantu homozygous, heterozygous, and non-Dantu). They found that Dantu polymorphism inhibits the invasion of RBCs by P. falciparum and that the effect is mediated by membrane tension rather than membrane protein expression levels.
For the full report of Day 3 see pdf attached
This report is brought to you by the MESA Correspondents. Senior editorial support has been facilitated by the Organizers and Co-Chairs of the symposia, Valentina Mangano (University of Pisa) and Julie Chaccour (Independent Consultant). This report is cross-posted on the MESA website and on MalariaWorld.