Are hypnozoites the only source of relapse-like, recurrent Plasmodium vivax malaria? They might not be. See explanation here [click] (however, note from the website link provided in a response to the blog, the new angle re erythrocytic parasites that was published online on 30 March 2017). Until such time as the matter has been cleared up via research, perhaps it would be appropriate to avoid expressing theoretical mathematical analyses (that incorporate hypnozoites) too restrictively. Merely a suggestion.