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Job: Postdoctoral Fellow - Malaria: sporozoite-host interactions

April 21, 2017 - 13:02 -- MalariaWorld Jobs


Salary range: £31,115 to £39,004 depending on experience.
Closing date for applications: 25th April 2017
Post available for 3 years initially


The Sanger Institute Malaria Programme consists of several faculty groups who use genomics and functional assays to understand the basic mechanisms of parasite biology with the aim of identifying new intervention targets.

There is an opening for a postdoctoral position in Dr Gavin Wright’s laboratory to take part in the H2020 OptiMalVax consortium. The project aims to identify and functionally characterise cell surface receptor-ligand interactions between the Plasmodium sporozoite and host that are essential for infection.

The role purpose is to develop and implement innovative experimental methods to deepen our molecular understanding of how Plasmodium sporozoites interact with their mammalian hosts. The primary objective will be to identify host cell surface receptors for Plasmodium sporozoite ligands using the receptor identification technologies that have been developed in the Wright laboratory. Where possible, the identified interactions will be functionally characterised by using the P. berghei infection model: the Institute has access to the full parasite lifecycle and parasite genomic tools as well as excellent transgenic mouse facilities.

Essential Skills

  • PhD in experimental analysis of Plasmodium parasites, ideally rodent Plasmodium infection models
  • Strong molecular biology skills
  • Outstanding communication skills, to ensure good interactions across multiple research teams; able to communicate effectively about complex technical matters with both experts and non-experts
  • Excellent organization and record keeping skills
  • Ability to deliver high-quality scientific outputs

Ideal Skills

  • Cell culture, recombinant protein expression and purification
  • Experience in using transgenic mice

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application. 

Closing date for applications: 25th April 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

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