Title of the PhD project: Evaluation of the effectiveness of different types of bi-treated long lasting insecticidal nets against pyrethroid resistant malaria vectors in Tanzania
Supervisor: Natacha Protopopoff (LSHTM)
Co-supervisor: Mark Rowland (LSHTM)
Organsiations: the London School of Hygiene & tropical Medicine, University of Ottawa and the National Institute for Medical Research Tanzania
Description overall RCT
Insecticide resistance in malaria vectors across Africa is the most serious problem facing malaria control progress. Policy has recently shifted away from pyrethroid-only long lasting insecticidal nets to next generation LLIN combining either two types of insecticide or pyrethroid plus synergist. Several types of bi-treated net (and evaluated in small scale entomological trials) demonstrate great potential to combat the threat and maintain control of malaria transmitted by resistant mosquitoes in Africa. The propose study is a cluster randomised controlled trial which compares new vector control interventions involving the most promising new generation LN to prevent malaria in areas where vector mosquitoes are resistant to pyrethroids in Tanzania. The RCT aim to produce evidence on the relative effectiveness of these alternative LLIN against malaria infection (prevalence and incidence) and transmission to help define future malaria control policy
The collaboration is between the London School of Hygiene & Tropical Medicine (LSHTM), University of Ottawa (UOttawa), and the National Institute for Medical Research (NIMR) in Mwanza and Kilimanjaro Christian Medical University College (KCMUCo) two major malaria research organisations in Tanzania. LSHTM and the two Tanzanian institutions form the PAMVERC alliance of trial sites (Pan African Malaria Vector Control Consortium) which have worked together since 2002 and on CRT since 2010. The trial is funded under the Global Health trial DFID/MRC/NIHR/Wellcome Trust.
Description PhD project
The PhD will be nested within the main community cluster-randomized trials. The PhD will focus more specifically on the impact of the interventions on entomological outcomes for 3 years (the lifespan of the LLIN).
The specific objectives of the PhD project are:
- to assess the impact of the bi-treated LLIN on Anopheles density (outdoor and indoor), species composition and entomological inoculation rate through routine entomology surveys
- to monitor the selection of resistance of the main vector to insecticide, using resistance frequency and intensity bioassays and following CYP6’s a subfamily of P450 enzymes
- to evaluate insecticide and textile durability of the LNs: 1) net survivorship, 2) fabric integrity and 3) insecticidal activity as per WHO protocol.
During the course of the PhD the student will be able receive some training, depending on needs, in data management, statistical analysis, GIS and basic epidemiology, good clinical/laboratory practice and laboratory (molecular characterisation).
PhD candidate requirements
• MSc training in parasitology and entomology (essential)
• Willing to be based in Tanzania (or at least part of PhD)
• Statistical and epidemiology expertise or aptitude
More information: read the project advertisment here.
To apply for this PhD position, click here to go to the application procedure at 2018-19 MRC LID Studentships
Don't forget to mention MalariaWorld when applying for this position!