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IVCC and Syngenta reach key milestone in development of new insecticide for malaria mosquito control

April 23, 2010 - 09:22 -- Mark Birchmore

IVCC and Syngenta reach key milestone in development of new insecticide for malaria mosquito control.

• Field trials show Actellic® 300CS can provide at least 8 months control of pyrethroid resistant mosquitoes
• Actellic® 300CS micro-encapsulated formulation submitted to WHOPES
• Major step forward in development of new products for malaria control

The Innovative Vector Control Consortium (IVCC) and Syngenta announced today that the latest field trials of the new Actellic® 300CS micro-encapsulated formulation demonstrate effective control of pyrethroid resistant mosquitoes on treated construction materials for more than eight months. Developed by Syngenta, and tested in laboratory and field evaluations by Syngenta and IVCC partner laboratories in Switzerland and Africa, Actellic® 300CS has subsequently been submitted to the World Health Organization Pesticide Evaluation Scheme (WHOPES) for independent performance and safety assessment. A recommendation from the WHO at the end of the evaluation process is a key requirement for many aid funded malaria control programs.

“The field data for Actellic 300CS has surpassed our original expectations and shows real promise as a valuable tool to complement our existing products,” said Mark Birchmore, Syngenta’s Global Brand Manager for Vector Control. “Working together with the IVCC enables us to leverage our expertise and capabilities to develop new products that meet the needs of current and future malaria control programs.”

Actellic® 300CS is the result of applying advanced micro-encapsulation technology to the WHO recommended insecticide pirimiphos-methyl to develop a new long lasting product which targets malaria mosquitoes resistant to the pyrethroid class of insecticides. Current alternatives to pyrethroids typically last for three months after application, resulting in additional costs and complexity for malaria programs. The submission to WHOPES is a major step forward in making the product available to national malaria control programs.

Dr Tom McLean, IVCC’s Chief Operating Officer, said: “The more effective control of mosquitoes is vital to the fight against malaria. Current tools can be highly effective but resistance threatens the effectiveness of existing products. We need innovative solutions to sustain the ground gained over malaria in recent years and to continue the push towards eventual eradication. This project amply demonstrates that IVCC’s concept of covering initial risk to stimulate innovation is working and that industry has enthusiastically bought into the product development partnership model which we have pioneered for vector control.”

Syngenta and the IVCC have been collaborating on projects to develop novel products for improved vector control since 2007. A second key project includes leveraging Syngenta’s vast compound collection and research expertise to specifically search for new insecticides for adult mosquito control. Early results are very encouraging with a number of separate chemical classes showing promise for further development.

Syngenta is one of the world's leading companies with more than 25,000 employees in over 90 countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to www.syngenta.com

The IVCC is a Product Development Partnership (PDP) established as a not for profit company and registered charity to overcome the barriers to innovation in the development of new insecticides for public health vector control and to develop information systems and tools which will enable new and existing pesticides to be used more effectively. For more information please go to www.ivcc.com