Although the recent article by Bo Xiao and others - cited below - presents negative aspects of genetic manipulation for introducing permanent changes in the parasite genome of Plasmodium falciparum, the positive aspects of this technique are enormous if one thinks of applying it to vector mosquitoes. Manipulating anopheline females so that they lay mostly male eggs could be the first step in species eradication in Africa for An gambiae and other major vectors. This would be a radical improvement in our tools for the fight against malaria.