This anthelminthic is extensively used as veterinary medicine to control gastro-intestinal helminthes, liver flukes and lungworms. It enters into the environment primarily through its excretion, 98% in faeces
Halley BA, Nessel RJ, Lu AYH, Chemosphere. 1989. 18, 1543-1563.
Ivermectin may be stored for long periods in soil.
Mougin C, Kollmann, A Galtier P. Envir Chem Lett 2003, 1, 131,-134.
The potential of anthelminthics to affect dung decomposition is well known, affecting dung beetles, dung flies and epigeic eathworms.
Wall R, Beynon S, Med Vet Entomol. 2012, 26, 1-8.Contamination is not limited to soil and dung; Ivermectin may leach into groundwater and reach water-bodies. It has been shown to be be toxic to a number of aquatic invertebrates.
Burridge LE, Haya K, Aquaculture, 1993, 117, 9-14
As Ivermectin kills flies and other insects like Anopheles gambiae, mass drug administration of Ivermectin into humans has proposed for malaria vector control.
S Omura, A Crump, Malaria Journal, 2017 16:172
The mosquito sucking human blood will also ingest a lethal concentration of ivermectin. In light of the above mentioned ecotoxic effects and possible effects on human health at high doses this proposal requires further investigations. Artemisia infusions which eliminate all parasites during malaria infections, including gametocytes, are probably a preferable to this chemical.
P Lutgen, J Munyangi, L Cornet-Vernet. 2016. Artemesia Plants: A Deadly Weapon Against Tropical Diseases. International Journal of Clinicall Research & Trials. Vol. 1. P. 108