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E-interview with Dr. Vincent Corbel (Benin, 1976)

March 19, 2010 - 10:19 -- Bart G.J. Knols

Dr. Corbel is currently a senior researcher at IRD, and based at the CREC in Cotonou in Benin. Following five years of heading the WHO collaborating centre for the evaluation of new public health pesticides he moved to Benin where he undertakes highly interesting studies aimed at improving vector control across Africa.

Q: Dear Vincent, you are currently heading the IRD vector control unit in Benin. What is your mandate?

 

A: My mandate is to lead a Vector Control group in Benin in close collaboration with our Partner, Prof. Martin Akogbeto who is the director of CREC. My projects relate to the genetics of resistance, the mode of action of insecticides and repellents and the evaluation of innovative Insecticide resistance management strategies under field conditions (Phase II & phase III). For instance, we’ve conducted a randomized controlled trial in Southern Benin between 2007 and 2010 aiming at evaluating the entomological and epidemiological impact of combining interventions (i.e. LLIN plus IRS-like with carbamate). Results showed clear benefits in using the two interventions over the mono-treatment (LLIN) in terms of reduction of malaria transmission and malaria episodes compared to the control group (LLIN) as well as for delaying the spread of pyrethroid (kdr) resistance in malaria vectors. We are now finalizing the data analysis and publications shall come very soon.



Q: You are also involved in the International Master of Medical Entomology course. Tell us more about this.

 

The International Master of medical and veterinary Entomology (IME) is a teaching programme for 2nd year Master students (M2.) coming from the South and the North. Its scientific and educational objectives are to develop a comprehensive training on the research areas of biology, vector systematic and ecology, population genetics, genomics and vector control. The IME has become part of the training programme offered to students at two universities: Université d'Abomey-Calavi (UAC - Benin) and Université de Montpellier2 (UM2 - France). More information can be obtained by contacting Dr. Thierry Baldet, Coordinator (thierry.baldet@ird.fr) and by visiting the Master’s website: http://www.miemv.org.

 

Q: You are about to publish a study where a combination of carbamate-treated indoor plastic sheeting was combined with the use of Lon-lasting treated bednets. What was the purpose of this, and how do you see this developing in future?

 

You are talking about the 2 papers published in Malaria Journal and American Journal of Tropical Medicine and Hygiene. Here the scope was to combine in a same dwelling an LLIN plus a Carbamate Treated Plastic sheeting (CTPS) to improve the personal protection and killing effect against pyrethroid-resistant mosquitoes. The rationale behind this concept is that neither LLIN nor IRS-like treatments will be sufficiently effective alone to achieve and maintain interruption of transmission in stable malaria areas of Africa. It was indeed essential to assess whether combining the two interventions could maximize the impact of malaria vector control and offer opportunities for the management of insecticide resistance (i.e. IRM strategy). Results were very promising and we are now working closely with industry (BES) to develop Long Lasting technology of “CTPS” for malaria control.

  

Q: You are also working on mosaic LLINs. What are these and what can these do?

 

Five years ago IRD investigated in experimental huts in Côte D’Ivoire the efficacy of insecticide mixtures and mosaics against pyrethroid-resistant mosquitoes. Despite interesting findings, we faced difficulties to go ahead with these mixtures because of the existence of synergistic interactions between the two compounds that might lead to adverse effects on humans. In contrast, mosaics didn’t show this drawback. Thanks to the Anopheles Biology & control network, we have recently conducted a multi centre study in West and Central Africa to evaluate the impact of a new mosaic Long-Lasting nets (combining deltamethin and PBO on the roof) for improving efficacy against pyrethroid-resistant mosquitoes. The outcomes of this study shall be published soon in Malaria Journal.

 

Q: Who would you like to see interviewed next, and why?

 

I suggest interviewing Dr Arjen M. Dondorp who has made excellent work and publications in the field of Antimalarial-drug resistance in South East Asia. His finding on ACT resistance in P. falciparum if of great concern and could represent a serious threat for the global policy of malaria control and elimination in the future.

 

Thank you for your time and interest to contribute this e-interview to MalariaWorld.