COMMENT: For many years, it has traditionally been considered that Plasmodium malariae does not have a hypnozoite stage in its life cycle. Evidence for this has been thought to perhaps include the longevity of hepatocytes and what happens after inoculation of parasitized erythrocytes into the primate host (see hepatocyte and P. malariae sections, respectively). More recently, there have been suggestions that hypnozoites might, in fact, be present in the liver in P. malariae infections. This remains a possibility. Therefore, whether or not hypnozoites occur in the life cycle of P. malariae continues to be a subject for speculation.