Position: Staff Scientist
Organization: The Sanger Institute
Closing Date: 15 August 2016
Salary Range: £31033 to £39142 depending on experience
The Sanger Institute Malaria Programme generates and analyses large-scale datasets in order to understand Plasmodium biology, and identify and prioritise new drug and vaccine targets. As part of this programme, the Billker and Rayner teams have founded the Plasmodium Genetic Modification Project (PlasmoGEM) to develop new scalable technologies for Plasmodium experimental genetics, and apply them to carry out genome-scale genetic screens. Using recombineering to build gene targeting vectors, and next generation sequencing to phenotype multiple knockout lines in parallel, the PlasmoGEM team has generated quantitative growth rate data for >3,000 genes in the rodent P. berghei model. Aspects of this approach are now being transferred to the major human pathogen P. falciparum.
There is now an opening for a Staff Scientist in the Rayner lab to lead the delivery of large-scale Plasmodium falciparum experimental genetics projects. The candidate will collaborate with the PlasmoGEM team and the Sanger Cellular Genetics Pipeline to lead knockout screens of hundreds of genes. The primary objective is to deliver novel scientific projects that result in high impact publications. The successful candidate will be a strong team player, a self-starter and keen to make the most of this exciting opportunity. It would particularly suit postdoctoral fellows with experience in Plasmodium falciparum genetics, who want to lead and take responsibility for a larger project, and work in a deeply collaborative and technologically rapidly moving environment.
• PhD in biological sciences;
• Significant experience in experimental genetic approaches in P. falciparum or other Plasmodium species;
• Strong publication record in P. falciparum research, including first author high-impact publications;
• Experience in delivering Plasmodium research presentations to internal and external collaborators at scientific conferences;
• Outstanding communication and collaboration skills, to ensure good interactions across multiple research teams;
• Excellent organization and record keeping skills;
• Independence and motivation, a self-starter and problem solver;
• Focussed and inspirational approach to leadership, setting the standard for others to follow.
The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications. Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.
To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.
Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
Please include a covering letter and CV with your application.
Closing date for applications: 15th August 2016; however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.
To apply (online) for this position, click here.
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