Radboud UMC, The Netherlands
1 year with an extension of 2 years
Please apply before 26 October 2020
We are looking for an outstanding and motivated researcher to join our team on a multidisciplinary project in malaria vaccinology!
Recently, we uncovered naturally acquired immune responses that can target the transmission stages of malaria parasites. Individuals with this novel type of immunity can prevent the maturation of malaria parasites in the human body so these cannot be taken up by mosquitoes, thus breaking the deadly life cycle of the parasite. We also found that the presence of antibodies against a specific panel of surface antigens correlates with this type of immunity. In the next phase we will test whether antibodies against each of these targets can indeed block maturation, justifying their further development as malaria transmission blocking vaccine candidate.
This project has two aims:
- Purification of naturally acquired antibodies and generation of murine antibodies against a panel of identified targets
- Functional characterization of the obtained antibodies
You will work on the production of recombinant proteins in different expression systems and use these to generate antibodies in rodents. Furthermore, you will use the recombinant proteins to examine binding of naturally acquired antibodies to improve our understanding of the magnitude and relevance of this immune response in human populations naturally exposed to malaria. Finally, you will validate the activity of obtained antibodies in in vitro and in vivo models for parasite maturation and transmission.
The work will be done in close collaboration with our partners at the London School of Hygiene & Tropical Medicine and the University of Glasgow. The work involves and international multi-disciplinary team of researchers and involves visits to Glasgow and/or London to conduct experiments.
We are looking for an ambitious, talented researcher with a Ph.D. degree in biochemistry, molecular biology or immunology or a minimum of 3 years of work experience in one of these fields. When you will complete your PhD in the near future we also like to invite you to apply.
- A scientific interest in infectious diseases
- An independent and well-structured working style
- Well-developed social skills directed to work in an international team
- Strong motivation and ambition to succeed in scientific research
Candidates should send their applications including a motivation letter (max. 1 page), a CV (including a publication list and details of the content of Ph.D. research (if applicable) and subsequent appointment), and the names and contact details of two persons who can provide references to Prof. Bousema and Dr. Jore.
Additional information about the vacancy can be obtained from Prof. Teun Bousema, Full Professor and from dr. Matthijs Jore, Assistant Professor. Apply online using the following website:
Please apply before 26 October 2020.
Recruitment agencies are asked not to respond to this job posting.
Don't forget to mention MalariaWorld when applying for this postion!