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Artemisia afra irreversibly cures tuberculosis

November 16, 2021 - 21:19 -- Pierre Lutgen

Early this year we published the results of 15 case studies. In 2020 15 patients infected by tuberculosis had been cured after 3 weeks of administration of Artemisia afra infusions, alone or in combination with the WHO prescribed drugs.

      Daddy B, Lutgen P, Gisenya P. Breakthrough against tuberculosis: high efficacy of Artemisia afra infusions. Pharm Pharmacol Int J. 2021;9(2):58‒62.

Meanwhile in several countries of the Great Lakes, the tuberculosis of some 30 additional patients has been cured, mostly by Artemisia afra alone.

We wondered if relapses or reinfections had occurred in the patients who had been cured a year ago in North Kivu. This is a critical issue, as it is well known that after the treatment with the prescribed WHO antibiotics relapses or reinfections are frequent.

       van Rie A, Warren R, Richardson M, Victor TC, Gie RP, Enarson DA, et al. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. The New England journal of medicine. 1999; 341(16):1174–9. https://doi.org/10.1056/NEJM199910143411602 PMID: 10519895. 

       den Boon S, van Lill SW, Borgdorff MW, Enarson DA, Verver S, Bateman ED, et al. High prevalence of tuberculosis in previously treated patients, Cape Town, South Africa. Emerging infectious diseases. 2007; 13(8):1189–94. https://doi.org/10.3201/eid1308.051327 PMID: 17953090.

Dr Bati Daddy visited 10 of these 15 patients dispersed in their villages in this large province of North Kivu, in March, May and September 2021. All 10 patients remain in good health and clinical checks showed absence of Mycobacterium tuberculosis  in their sputum. They had not consumed Artemisia infusions since their release from the hospital end of 2020, because the plant material is not available in their villages. Detailed data concerning the results of these visits and checks are available on request.

This is an extraordinary breakthrough. A discovery made by African medical doctors.

Trying to understand why Artemisia afra is so efficient against TB is a fascinating task. In a blog which I posted 7 years ago, I made a short reference to the effect of luteolin on Mycobacterium tuberculosis.

       Pierre Lutgen.  Luteolin in the Artemisia family. www.malariaworld.org . June 26, 2013

The highest concentration of luteolin in all medicinal herbs is found in Artemisia afra : 1.9 mg/g, In Artemisia absinthium only 0.7 mg/g are found and luteolin has not frequently been reported in Artemisia annua, on the average 20 times lower than in Artemisia afra. It is absent in Artemisia dracunculus.

        A Dube, Thesis, Artemisia afra, U Western Cape, 2006, 

Raymond Muganga. Luteolin levels in selected folkloric preparations and the bioavailability of luteolin from Artemisia afra aqueous extract in the vervet monkey.  UNR-Etudes Rwandaises. 2007, 14, 100-111

Based on these early inputs, I was fortunate to find an important paper, dated August 2021.

       Singh DK, Tousif S, Bhaskar A, Devi A, Negi K, Moitra B, et al. (2021). Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis. PLoS Pathog 17(8): e1009805. https://doi.org/10.1371/journal.ppat.1009805

They find in a murine test that luteolin, when administered along with isoniazid as potential host directed therapy promotes anti-TB immunity, reduces the length of TB treatment and prevents disease relapse. Luteolin also enhances long-term anti-TB immunity by promoting central memory T cell responses. Furthermore, they found that Luteolin enhances the activities of natural killer and natural killer T cells, both of which exhibit antitubercular attributes. Therefore, the addition of luteolin to conventional antibiotic therapy may provide a means to avoid the development of drug-resistance and to improve disease outcome.

Analysis of the gross pathology of the lungs at 60 dpi revealed fewer and smaller granuloma-like consolidations in mice treated with a combination of luteolin and isoniazid, by apoptosis rather than necrosis.

Treatment with luteolin dramatically reduced susceptibility to re-infection and re-activation of TB disease as compared with animals that received conventional antibiotics only. TB infected mice treated with luteolin also become less infectuous for other mice in the vicinity.

They also find that luteolin increases the CD4 lymphocytes, which confirms the findings of Dr Constant Tchandema in 2013 ; results which are quoted by WHO in their Artemisia statement of Oct 10, 2019.

        Tchandema CK, Lutgen P. In vivo trials on the therapeutic effects of encapsulated Artemisia annua and Artemisia afra. Glob J Res Anal. 2016;5(6):228–34. doi:10.15373/2249555X.

According to WHO 1.74 million TB deaths are reported annually. 4x more than for malaria !

Global tuberculosis report 2017. Geneva: World Health Organization; 2017. 157 p