Global Malaria News
Malaria could be felled by an Antarctic sea sponge
The frigid waters of the Antarctic may yield a treatment for a deadly disease that affects populations in some of the hottest places on earth. Current medications for that scourge -- malaria -- are becoming less effective as drug resistance spreads. But researchers report that a peptide they isolated from an Antarctic sponge shows promise as a lead for new therapies.
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Diversity of Plasmodium falciparum across Sub-Saharan Africa
Scientists have identified the regional character to Plasmodium falciparum across Africa. Malaria, infecting 219 million individuals in 2017, remains a threat to public health and regional stability. Human movement and the introduction of antimalarial drugs were drivers of this genetic diversity. Gene flow between sub-populations could spread resistance from one sub-population to the rest of the continent.
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Genome mining reveals novel production pathway for promising malaria treatment
Researchers are exploring the relationship between microbial natural products and the gene clusters that enable their production. By learning to recognize what genes lead to what types of products, they hope to use genome sequencing to speed discovery of new natural products that may have key therapeutic properties.
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By comparing needles to mosquitoes, new model offers insights into Hepatitis C solutions
Removing used needles does not reduce the spread of Hepatitis C virus -- instead, changing the ratio of infected to uninfected needles is critical, study finds.
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Biomarker predicts if someone infected with malaria will get sick
Increased p53, the well-known tumor-suppressor protein, can predict whether malaria-infected children will develop fever or other symptoms, suggests a new study. The authors say the findings could lead to new strategies for dampening the harmful inflammatory responses associated with some infections and identifying individuals who might be at risk for such responses.
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Immortalized blood cell lines enable new studies of malaria invasion
Researchers have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.
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Mosquito incognito: Could graphene-lined clothing help prevent mosquito bites?
A new study shows that graphene sheets can block the signals mosquitoes use to identify a blood meal, potentially enabling a new chemical-free approach to mosquito bite prevention.
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To stop mosquito-transmitted illnesses, pay attention to how humans behave
Targeting the mosquito population within a defined area is the primary way scientists and public health officials mitigate the spread of diseases caused by viruses like Zika, dengue fever, and West Nile. But researchers have discovered that evaluating how humans commute to and from an affected area, as well as their living habits, is key for successful mitigation planning.
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Genes tell the story of how the Asian tiger mosquito spread
Over the last 40 years, the Asian tiger mosquito, Aedes albopictus, has invaded every continent thanks to the transportation of its eggs via human trade and transportation. Researchers have now used the genomes of the mosquitoes to track the history of the invasion and expansion of the species through Albania, Italy, and Greece.
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Malaria control success in Africa at risk from spread of multi-drug resistance
In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum parasites that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs. This sheds new light on the way that drug resistance is emerging in different locations and moving by various routes across Africa, putting previous success in controlling malaria at risk.
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Map of malaria behavior set to revolutionize research
The first detailed map of individual malaria parasite behavior across each stage of its complicated life cycle has been created by scientists. Researchers used advanced single-cell technology to isolate individual parasites and measure their gene activity. The result is the Malaria Cell Atlas, which gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites change as they develop in both the mosquito and human host.
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An unreported Zika outbreak in 2017 detected through travel surveillance and genetics
By sequencing virus genomes from infected travelers, analyzing travel patterns and mosquito modeling, researchers unearthed a spike in Zika cases from travelers returning from Cuba during the summer of 2017 that was not captured by local reports.
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Malaria expert warns of need for malaria drug to treat severe cases in US
The US each year sees more than 1,500 cases of malaria, and currently there is limited access to an intravenously-administered (IV) drug needed for the more serious cases.
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Monkey malaria breakthrough offers possible cure for relapsing malaria
A breakthrough in monkey malaria research could help scientists diagnose and treat a relapsing form of human malaria.
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Mosquito 'spit glands' hold key to curbing malaria, study shows
Mosquitoes can harbor thousands of malaria-causing parasites in their bodies, yet while slurping blood from a victim, they transmit just a tiny fraction of them. In an effort to define precisely the location of the parasite bottleneck, scientists say they have discovered that the parasites are stopped by a roadblock along the escape route in the insect's spit glands, a barrier that could potentially serve as a novel target for preventing or reducing malarial infection.
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Selective antibiotics following nature's example
Chemists develop selective agents to combat infectious diseases -- based on the structures of natural products.
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Keeping parasites from sticking to mosquito guts could block disease transmission
Infections such as Chagas disease, African sleeping sickness, and leishmaniasis are caused by a group of microorganisms called kinetoplastids. In a new study, a research team used a non-disease-causing kinetoplastid to investigate how these parasites adhere to their insect hosts' insides. Their findings could help in the development of targeted therapies that prevent insects from transmitting these diseases to humans.
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Copy-number variants in development of insecticide resistance in malaria mosquitoes
Researchers have used whole genome sequencing to understand copy-number variants (CNVs) in malaria mosquitoes and their role in insecticide resistance.
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Trapping female mosquitoes helps curb chikungunya virus
The US Centers for Disease Control and Prevention (CDC) recently developed an Autocidal Gravid Ovitrap (AGP trap) that attracts and captures female mosquitoes looking for a site to lay eggs. Now, researchers report that AGO traps successfully protected people from infection with chikungunya virus (CHIKV) in communities in Puerto Rico.
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Multidrug-resistant malaria spreading in Asia
Genomic surveillance has revealed that malaria resistance to two first-line antimalarial drugs has spread rapidly from Cambodia to neighboring countries in Southeast Asia. Researchers discovered that descendants of one multi-drug resistant malaria strain are replacing the local parasites in Vietnam, Laos and northeastern Thailand, and are picking up additional new genetic changes which could further enhance resistance. The study reveals the importance of ongoing genomic surveillance in malaria control strategies.
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