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Global Malaria News

Vaccinating humans to protect mosquitoes from malaria

Science Daily - October 9, 2018 - 13:15
Scientists have been trying to develop a vaccine that prevents mosquitoes from spreading malaria among humans. This unique approach -- in which immunized humans transfer anti-malarial proteins to mosquitoes when bitten -- is called a transmission-blocking vaccine (TBV). A new biotech advancement moves us closer to this goal.

How malaria infection activates natural killer cells

Science Daily - October 4, 2018 - 18:39
Malaria-infected red blood cells trigger the immune system's first line of defense by releasing small vesicles that activate a pathogen recognition receptor called MDA5, according to a new study.

Rewriting the textbook on how steroid hormones enter cells

Science Daily - October 4, 2018 - 18:39
A discovery may open up new ways to control steroid hormone-mediated processes, including growth and development in insects, and sexual maturation, immunity, and cancer progression in humans.

Malaria parasites adapt to mosquito feeding times, study shows

Science Daily - October 4, 2018 - 15:00
Malaria parasites have evolved to be most infectious at the time of day when mosquitoes feed, to maximize their chances of being spread.

Tiger mosquitoes are capable of transmitting yellow fever

Science Daily - September 26, 2018 - 15:08
Since December 2016, Brazil has been grappling with its worst yellow fever outbreak for several decades. Research has now demonstrated that the yellow fever virus can be transmitted via Aedes albopictus, the tiger mosquito. This opportunistic species is capable of colonizing both urban and forest areas.

Parasite makes quick exit when researchers remove the handbrake

Science Daily - September 24, 2018 - 18:40
Researchers have discovered a way to halt the invasion of the toxoplasmosis-causing parasite into cells, depriving the parasite of a key factor necessary for its growth. The findings are a key step in getting closer to a vaccine to protect pregnant women from the parasite Toxoplasma gondii, which carries a serious risk of miscarriage or birth defects.

Mosquitoes that can carry malaria eliminated in lab experiments

Science Daily - September 24, 2018 - 15:59
Researchers have eliminated caged mosquitoes using 'gene drive' technology to spread a genetic modification that blocks female reproduction.

Anti-cancer drugs may hold key to overcoming antimalarial drug resistance

Science Daily - September 20, 2018 - 14:21
Scientists have found a way to boost the efficacy of the antimalarial drug artemesinin with the help of chemotherapy medicines. Artemisinin works through a 'double whammy' attack on the deadly parasite. The drug damages proteins in malaria parasites and clogs the parasite's waste disposal system, known as the proteasome, which chemo can target.

A new approach towards developing a vaccine against vivax malaria

Science Daily - September 20, 2018 - 14:21
A study indicates the possibility of using tiny vesicles derived from human immature red blood cell as a vaccine platform.

Drugs that stop mosquitoes catching malaria could help eradicate the disease

Science Daily - September 18, 2018 - 12:20
Researchers have identified compounds that could prevent malaria parasites from being able to infect mosquitoes, halting the spread of disease.

Coartem and Dayquil

Malaria.com news - September 13, 2018 - 17:09
Question: Can we take Dayquil / Nyquil while treating malaria with Coartem?

A computational analysis identifies a new clinical phenotype of severe malaria

Science Daily - August 31, 2018 - 15:03
There are more clinical phenotypes of severe malaria than those defined by the World Health Organization (WHO), according to a new study. The results indicate that heart failure can be a pathogenic mechanism of disease, which has implications in the clinical management of these patients.

Simple test detects disease-carrying mosquitoes, presence of biopesticide

Science Daily - August 30, 2018 - 18:32
A new tool uses a smartphone camera, a small 3D-printed box and a simple chemical test to show whether a dead mosquito belongs to the Aedes aegypti species, which carries Zika and other devastating viruses that afflict an estimated 100 million people worldwide each year.

Heart-brain connection could be predictive biomarker for epilepsy

Science Daily - August 27, 2018 - 17:44
Heartbeat irregularities connected to brain activity abnormalities may lead to the ability to predict eventual epileptic seizures in subjects who suffered physical or infectious brain insults, according to Penn State researchers who studied mouse models of cerebral malaria, which often causes epilepsy in those who survive.

Lower-risk malaria regions are breeding grounds for drug-resistant strains

Science Daily - August 21, 2018 - 18:52
New drug-resistant strains of the parasite that causes malaria tend to evolve in regions with lower malaria risk; in areas with high transmission rates, they get outcompeted by the more common, drug-sensitive strains inside the human host. In high-transmission settings, it takes a long time for drug-resistant strains to take hold, but once they do, they can spread rapidly, according to a new study.

AMF is hiring! Data Analyst

Against Malaria news - August 21, 2018 - 11:06

AMF's net distributions continue to grow and with this comes the need for us to analyse the data we receive to ensure every distribution has the maximum impact. We are now seeking exceptional candidates for the role of Data Analyst.

Reporting to AMF’s Operations Manager, and working closely with all the other members of the AMF team, the successful candidate will have strong technical skills but also be open, collegiate and enjoy working in a small, highly impactful team.

The Data Analyst will have exceptional organisational and analytical skills, together with a bias for identifying and solving issues. They will have strong attention to detail and excel capability, appreciate the importance of visual presentation of material for clarity and an interest in using data to improve health outcomes for the poorest communities. They will be comfortable learning about financial matters, and be willing to examine budgets in detail.

Prior experience in international development is not necessary. For the right candidate AMF would be willing for them to have flexible working arrangements.

The current members of the AMF team are based in their home offices, and it would be ideal if the Data Analyst is able to do the same. The successful candidate is likely to be in the UK/Europe/Africa time zones.

Job description and details of how to apply

Next-gen insect repellents to combat mosquito-borne diseases

Science Daily - August 20, 2018 - 12:52
Nearly 700 million people suffer from mosquito-borne diseases -- such as malaria, West Nile, Zika and dengue fever -- each year, resulting in more than 1 million deaths. Today, researchers report a new class of mosquito repellents based on naturally occurring compounds that are effective in repelling the bugs, including those that are resistant to pyrethroid insecticides and repellents.

Milestone: 75 million nets!

Against Malaria news - July 25, 2018 - 15:41

We are delighted to say we have now reached a cumulative total since AMF started of 75 million nets funded or able to be funded!

This has been possible through the support of 111,000 people in 189 countries who have made 348,468 donations. Thank you!

Once all are distributed, these nets, protecting 135 million people, can be expected to prevent the deaths of 50,000 to 70,000 people and avert 50 to 70 million cases of malaria.

Our first net distribution was in 2006 and was of 3,000 nets and our largest distribution to date has been of 12.8m nets in 2017. The total number of nets distributed or planned for distribution is 41.5m nets and distributions totalling more than 30m nets are being assessed now. The net distributions we now fund are multiple millions of nets at a time as this is the way we can best contribute to the fight against malaria.

There is a significant gap between the nets we can fund and the requests we currently have so we will continue to work hard to contribute all we can to close the net gap.

Good read: 'Mosquito: The Story of Man's Deadliest Foe'

Against Malaria news - July 24, 2018 - 14:30

This is an accessible book that tells the story of malaria very well.

I have just finished reading it and would recommend it if you are looking for an easy, enjoyable read that leaves you with a much greater understanding of the how and why of malaria.

The book focuses on people and countries and is not at all technical.

Dr Andrew Spielman and Michael D'Antonio wrote the book in 2002 so it doesn’t cover the last 15+ years of progress fighting malaria but it is no less relevant for that. In fact, many of the stories of malaria – the victories and subsequent resurgence – are as relevant today as when the book was written.

If you have recommendations for other books that similarly tell well the story of malaria please do let me know.

Declaration: I have no connection with the authors and neither AMF, nor anyone associated with AMF, has any financial interest in the book or its sales.

Congratulations to extraordinary Atlantic Challenge 'Oardinary Boys' Oli and George

Against Malaria news - July 16, 2018 - 14:33

Hot on the heels of our previous blogpost, albeit completed before, we’d like to offer our admiration and congratulations to the not-so Oardinary Boys, Oli Glanville and George Randell, for successfully Rowing the Atlantic - 3,000 miles in a very small boat.

And they didn’t just row it, they smashed it: they are now the second fastest pair in history to row the Atlantic.

Oli and George took part in the 2017 Talisker Atlantic Challenge, setting off from San Sebastian in the Canary Islands at 6am UTC on 14 December 2017. They made land in English Harbour, Antigua and Barbuda at 22:01 UTC on 20 January 2018, just 37 days, 16 hours and 1 minute later.

This is an extraordinary challenge: 2 hours rowing, 2 hours rest, for a period of up to 60 days. Relentless. Non-stop. Burning 10,000 calories a day, consuming 6,000. You lose 20% of your body weight. 1.5 million oar strokes. It would require paragraphs here to give even a flavour of the dedication, training, strength – both physical and mental – discomfort and pain that goes into completing a successful Atlantic Challenge. We'll leave you to imagine it, if you can.

Oli and George chose to have two charities benefit from their pain and efforts, Alzheimer's Research UK and AMF.

We are delighted to report they raised an extraOARdinary £26,419 for AMF, 100% of which has been used to buy 18,606 long-lasting insecticidal nets (LLINs) to protect 33,500 people when they sleep at night from the bites of malaria-carrying mosquitoes - that would otherwise cause severe illness, or worse. That's the equivalent of 67 entire villages covered. These nets can be expected to save the lives of 10 to 15 people and prevent 13,000 cases of malaria.

Oarsome. HUGE congratulations Oli and George – and thank you.

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