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Immortalized blood cell lines enable new studies of malaria invasion

Science Daily - August 29, 2019 - 14:28
Researchers have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.

Mosquito incognito: Could graphene-lined clothing help prevent mosquito bites?

Science Daily - August 26, 2019 - 19:07
A new study shows that graphene sheets can block the signals mosquitoes use to identify a blood meal, potentially enabling a new chemical-free approach to mosquito bite prevention.

To stop mosquito-transmitted illnesses, pay attention to how humans behave

Science Daily - August 26, 2019 - 19:06
Targeting the mosquito population within a defined area is the primary way scientists and public health officials mitigate the spread of diseases caused by viruses like Zika, dengue fever, and West Nile. But researchers have discovered that evaluating how humans commute to and from an affected area, as well as their living habits, is key for successful mitigation planning.

Genes tell the story of how the Asian tiger mosquito spread

Science Daily - August 22, 2019 - 18:19
Over the last 40 years, the Asian tiger mosquito, Aedes albopictus, has invaded every continent thanks to the transportation of its eggs via human trade and transportation. Researchers have now used the genomes of the mosquitoes to track the history of the invasion and expansion of the species through Albania, Italy, and Greece.

Malaria control success in Africa at risk from spread of multi-drug resistance

Science Daily - August 22, 2019 - 18:19
In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum parasites that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs. This sheds new light on the way that drug resistance is emerging in different locations and moving by various routes across Africa, putting previous success in controlling malaria at risk.

Map of malaria behavior set to revolutionize research

Science Daily - August 22, 2019 - 18:19
The first detailed map of individual malaria parasite behavior across each stage of its complicated life cycle has been created by scientists. Researchers used advanced single-cell technology to isolate individual parasites and measure their gene activity. The result is the Malaria Cell Atlas, which gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites change as they develop in both the mosquito and human host.

An unreported Zika outbreak in 2017 detected through travel surveillance and genetics

Science Daily - August 22, 2019 - 15:33
By sequencing virus genomes from infected travelers, analyzing travel patterns and mosquito modeling, researchers unearthed a spike in Zika cases from travelers returning from Cuba during the summer of 2017 that was not captured by local reports.

Malaria expert warns of need for malaria drug to treat severe cases in US

Science Daily - August 19, 2019 - 21:57
The US each year sees more than 1,500 cases of malaria, and currently there is limited access to an intravenously-administered (IV) drug needed for the more serious cases.

Monkey malaria breakthrough offers possible cure for relapsing malaria

Science Daily - August 15, 2019 - 14:15
A breakthrough in monkey malaria research could help scientists diagnose and treat a relapsing form of human malaria.

Mosquito 'spit glands' hold key to curbing malaria, study shows

Science Daily - August 12, 2019 - 17:08
Mosquitoes can harbor thousands of malaria-causing parasites in their bodies, yet while slurping blood from a victim, they transmit just a tiny fraction of them. In an effort to define precisely the location of the parasite bottleneck, scientists say they have discovered that the parasites are stopped by a roadblock along the escape route in the insect's spit glands, a barrier that could potentially serve as a novel target for preventing or reducing malarial infection.

Selective antibiotics following nature's example

Science Daily - July 30, 2019 - 16:53
Chemists develop selective agents to combat infectious diseases -- based on the structures of natural products.

Keeping parasites from sticking to mosquito guts could block disease transmission

Science Daily - July 30, 2019 - 16:52
Infections such as Chagas disease, African sleeping sickness, and leishmaniasis are caused by a group of microorganisms called kinetoplastids. In a new study, a research team used a non-disease-causing kinetoplastid to investigate how these parasites adhere to their insect hosts' insides. Their findings could help in the development of targeted therapies that prevent insects from transmitting these diseases to humans.

Copy-number variants in development of insecticide resistance in malaria mosquitoes

Science Daily - July 26, 2019 - 13:46
Researchers have used whole genome sequencing to understand copy-number variants (CNVs) in malaria mosquitoes and their role in insecticide resistance.

Trapping female mosquitoes helps curb chikungunya virus

Science Daily - July 25, 2019 - 19:09
The US Centers for Disease Control and Prevention (CDC) recently developed an Autocidal Gravid Ovitrap (AGP trap) that attracts and captures female mosquitoes looking for a site to lay eggs. Now, researchers report that AGO traps successfully protected people from infection with chikungunya virus (CHIKV) in communities in Puerto Rico.

Multidrug-resistant malaria spreading in Asia

Science Daily - July 23, 2019 - 12:59
Genomic surveillance has revealed that malaria resistance to two first-line antimalarial drugs has spread rapidly from Cambodia to neighboring countries in Southeast Asia. Researchers discovered that descendants of one multi-drug resistant malaria strain are replacing the local parasites in Vietnam, Laos and northeastern Thailand, and are picking up additional new genetic changes which could further enhance resistance. The study reveals the importance of ongoing genomic surveillance in malaria control strategies.

Understanding the mode of action of the primaquine: New insights into a 70 year old puzzle

Science Daily - July 19, 2019 - 14:21
Researchers have taken significant steps in understanding the way that the anti-malarial drug primaquine (PQ) works, which they hope will lead to the development of new, safer and more effective treatments for malaria.

Getting to zero malaria cases in Zanzibar

Science Daily - July 10, 2019 - 17:19
New research suggests that a better understanding of human behavior at night -- when malaria mosquitoes are biting -- could be key to preventing lingering cases.

How the mosquito immune system fights off the malaria parasite

Science Daily - July 10, 2019 - 17:19
A new study describes the way mosquito immune systems fight malaria parasites using various waves of resistance. The study could lay the groundwork for future research to combat the transmission of malaria, which sickens millions of people across the globe every year.

Why do mosquitoes choose humans?

Science Daily - July 2, 2019 - 22:45
Most of the 3,000+ mosquito species are opportunistic, but researchers are most interested in the mosquitoes that scientists call 'disease vectors' -- carriers of diseases that plague humans -- some of which have evolved to bite humans almost exclusively. One expert is trying to understand how the brain and genome of these mosquitoes have evolved to make them specialize in humans -- including how they can distinguish us from other mammals so effectively.

Botox cousin can reduce malaria in an environmentally friendly way

Science Daily - June 28, 2019 - 16:05
Researchers have found a new toxin that selectively targets mosquitoes. This can lead to innovative and environmentally friendly approaches to reduce malaria.

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