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News (Scientific)

Experimental anti-malarial drug shows promise in first clinical trial

Science Daily - April 8, 2020 - 16:55
Malaria is a leading killer of children worldwide, and new drugs are needed. New research reports encouraging early clinical results with a new compound.

Is your coffee contributing to malaria risk?

Science Daily - March 9, 2020 - 13:30
Researchers estimate 20% of the malaria risk in deforestation hot spots is driven by the international trade of exports including: coffee, timber, soybean, cocoa, wood products, palm oil, tobacco, beef and cotton. The results of the study can be used for more demand-side approaches to mitigating malaria incidence by focusing on regulating malaria-impacted global supply chains.

Novel compound sparks new malaria treatment hope

Science Daily - March 4, 2020 - 19:15
A novel class of antimalarial compounds that can effectively kill malaria parasites has been developed. In preclinical testing, the compounds were effective against different species of malaria parasites, including the deadly Plasmodium falciparum, and at multiple stages of the parasite lifecycle. The compounds could overcome existing issues of parasite drug resistance. The researchers hope that drugs based on these early compounds will soon enter phase 1 clinical trials.

How malaria detects and shields itself from approaching immune cells

Science Daily - February 18, 2020 - 17:43
Malaria parasites can sense a molecule produced by approaching immune cells and then use it to protect themselves from destruction, according to new findings.

Eco-friendly way to stop mosquitoes

Science Daily - February 13, 2020 - 14:07
An innovative -- and inexpensive -- technique targets mosquito larvae where they live.

How the malaria parasite grows and multiplies

Science Daily - February 11, 2020 - 17:15
Scientists have made a major breakthrough in understanding how the parasite that causes malaria is able to multiply at such an alarming rate, which could be a vital clue in discovering how it has evolved, and how it can be stopped. For the first time, scientists have shown how certain molecules play an essential role in the rapid reproduction of parasite cells, which cause this deadly disease.

Discovery paves path forward in the fight against the deadliest form of malaria

Science Daily - February 8, 2020 - 14:43
Scientists have identified a key molecule involved in the development of cerebral malaria, a deadly form of the tropical disease. The study identifies a potential drug target and way forward toward alleviating this condition for which few targeted treatments are available.

A roadblock for disease-causing parasites

Science Daily - February 3, 2020 - 20:12
Thread-like parasitic worms cause millions of cases of canine heartworm each year, and more than 100 million cases of lymphatic filariasis, also known as elephantiasis, in humans. New research shows that ramping up the immune response of mosquitoes blocked their ability to transmit these harmful parasites.

Scientists discover how malaria parasites import sugar

Science Daily - January 29, 2020 - 18:15
Researchers have established how sugar is taken up by the malaria parasite, a discovery with the potential to improve the development of antimalarial drugs.

TP53 gene variant in people of African descent linked to iron overload, may improve malaria response

Science Daily - January 24, 2020 - 12:39
A rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial infections, along with markers of iron overload in African Americans. Macrophage iron accumulation disrupts their function, resulting in more severe bacterial infections.

Engineered capillaries model traffic in tiny blood vessels

Science Daily - January 23, 2020 - 20:25
3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.

A Zika vaccine could save suffering and costs

Science Daily - January 23, 2020 - 18:41
A new study found that routinely giving the Zika vaccine to women of childbearing age could save money if the risk of Zika is around that of other mosquito-borne diseases like dengue and chikungunya.

Mosquitoes are drawn to flowers as much as people -- and now scientists know why

Science Daily - January 22, 2020 - 13:05
Despite their reputation as blood-suckers, mosquitoes actually spent most of their time drinking nectar from flowers. Scientists have identified the chemical cues in flowers that stimulate mosquitoes' sense of smell and draw them in. Their findings show how cues from flowers can stimulate the mosquito brain as much as a warm-blooded host -- information that could help develop less toxic repellents and better traps.

Molecular understanding of drug interactions suggests pathway to better malaria treatments

Science Daily - January 15, 2020 - 21:40
Researchers have for the first time demonstrated what happens at the molecular level when two compounds known to inhibit crystal growth were combined, yielding new insights into malaria treatments and, more broadly, improving the process of drug development.

New study reveals the origin of complex malaria infections

Science Daily - January 8, 2020 - 21:03
New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease.

A new breakthrough in developing effective antimalarial drugs

Science Daily - December 31, 2019 - 16:18
Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular DNA methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparum parasites.

Researchers map malaria parasites proliferating in human blood cells

Science Daily - December 27, 2019 - 13:52
Malaria parasites transform healthy red blood cells into rigid versions of themselves that clump together, hindering the transportation of oxygen. The infectious disease affects more than 200 million people across the world and causes nearly half a million deaths every year, according to the World Health Organization's 2018 report on malaria. Until now, however, researchers did not have a strong understanding of how the parasite so effectively infiltrated a system's red blood cells.

Mosquitoes can sense toxins through their legs

Science Daily - December 26, 2019 - 13:44
Researchers have identified a completely new mechanism by which mosquitoes that carry malaria are becoming resistant to insecticide.

Gene drives work faster than non-drive approaches to control problem insects

Science Daily - December 19, 2019 - 19:26
When controlling mosquitoes that spread malaria, gene drives, which force genetic changes to proliferate in a population, are faster and more efficient than simply releasing mosquitoes that are immune to the parasite, according to a new study.

Safer viruses for vaccine research and diagnosis

Science Daily - December 11, 2019 - 19:47
A new technology to produce safer 'hybrid' viruses at high volumes for use in vaccines and diagnostics for mosquito-borne diseases has been developed.


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