Global Malaria News
TP53 gene variant in people of African descent linked to iron overload, may improve malaria response
A rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial infections, along with markers of iron overload in African Americans. Macrophage iron accumulation disrupts their function, resulting in more severe bacterial infections.
3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.
A new study found that routinely giving the Zika vaccine to women of childbearing age could save money if the risk of Zika is around that of other mosquito-borne diseases like dengue and chikungunya.
Despite their reputation as blood-suckers, mosquitoes actually spent most of their time drinking nectar from flowers. Scientists have identified the chemical cues in flowers that stimulate mosquitoes' sense of smell and draw them in. Their findings show how cues from flowers can stimulate the mosquito brain as much as a warm-blooded host -- information that could help develop less toxic repellents and better traps.
Researchers have for the first time demonstrated what happens at the molecular level when two compounds known to inhibit crystal growth were combined, yielding new insights into malaria treatments and, more broadly, improving the process of drug development.
New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease.
Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular DNA methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparum parasites.
Malaria parasites transform healthy red blood cells into rigid versions of themselves that clump together, hindering the transportation of oxygen. The infectious disease affects more than 200 million people across the world and causes nearly half a million deaths every year, according to the World Health Organization's 2018 report on malaria. Until now, however, researchers did not have a strong understanding of how the parasite so effectively infiltrated a system's red blood cells.
Researchers have identified a completely new mechanism by which mosquitoes that carry malaria are becoming resistant to insecticide.
When controlling mosquitoes that spread malaria, gene drives, which force genetic changes to proliferate in a population, are faster and more efficient than simply releasing mosquitoes that are immune to the parasite, according to a new study.
A new technology to produce safer 'hybrid' viruses at high volumes for use in vaccines and diagnostics for mosquito-borne diseases has been developed.
DNA from 75-year old eradicated European malaria parasites uncovers the historical spread of one of the two most common forms of the disease, Plasmodium vivax, from Europe to the Americas during the colonial period, finds a new study.
The first-ever detailed images of a malaria protein, a known key modulator of drug resistance, show how the parasite evades antimalarials -- and may help scientists find ways to restore the drugs' potency.
Engineers have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal settings needed to complete a given diagnostic task. In the initial proof-of-concept study, the microscope simultaneously developed a lighting pattern and classification system that allowed it to quickly identify red blood cells infected by the malaria parasite more accurately than trained physicians and other machine learning approaches.
A discovery about how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus, say researchers. The research team showed, in laboratory models, that strong inflammatory signals caused by malaria infection activate molecules that trigger the production of highly potent antibodies to fight the disease.
London schoolchildren have found -- with the help of scientists -- that some of their families' soup recipes have antimalarial properties.
Scientists have taken another big step forward towards developing a vaccine that's effective against the most severe forms of malaria.
A new study into the interplay between mobility and the 2013 and 2014 dengue outbreaks in Singapore has uncovered a legal void around access to mobile phone data -- information that can prove vital in preventing the spread of infectious diseases.
Cell biologists have systematically investigated the genome of the malaria parasite Plasmodium throughout its life cycle in a large-scale experiment. The researchers were able to identify hundreds of targets that are urgently needed in drug and vaccine development to eradicate the disease.
A discovery has the potential to inhibit the spread of West Nile virus as well as Zika and dengue viruses. The researchers demonstrated that mammalian insulin activated an antiviral immunity pathway in mosquitoes, increasing the insects' ability to suppress the viruses. Since mosquito bites are the most common way humans are infected with West Nile, stopping the virus among the insects would protect human health.