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  • Reply to: Haemolytic, hepatotoxic, cytotoxic, neurotoxic, cardiotoxic, genotoxic, ototoxic, embryotoxic, spleenotoxic, hemolytic, atherosclerosis, immunodepressive effects of chemical artemisinine derivatives (ACTs) at high doses.   6 days 31 min ago

    Is WHO aware that this high dose approaches toxic tresholds ?

    Where are the clinical trials which support this new pharmaceutical business ?


    WHO prequalifies the newest formulation of high strength Novartis' Coartem for malaria

    • The new WHO-prequalified formulation of Coartem combines 80 mg of artemether and 480 mg of lumefantrine.

    • The original formulation of Coartem was 20 mg of artemether and 120 mg of lumefantrine.

  • Reply to: Effective Program Management: A Cornerstone of Malaria Elimination   6 days 7 hours ago
    Moreover, Bart, professional cadres are important in advocating for malaria elimination and hence convincing the politician to support. The way they they do the work and the way they presenting the case is very important.
  • Reply to: Effective Program Management: A Cornerstone of Malaria Elimination   6 days 20 hours ago
    Dear Dr. Malik, I agree with your view entirely. What is needed is a cadre of professionals that can be in it (working towards malaria elimination and subsequently eradication) for the long run, are offered career perspectives and training opportunities as they learn on the job. This is how it was done in the old days in countries that succeeded in malaria elimination (e.g. Taiwan). Interestingly, looking at the latest poll result, it is 80% of the respondents to date (n=69) that consider political will in endemic countries as vital if we want to move towards global eradication. Surely, building a strong professional cadre in-country is key in that regard. Best wishes, Bart
  • Reply to: Effective Program Management: A Cornerstone of Malaria Elimination   1 week 1 day ago
    I think what suggested by the authors "practice-oriented research" is the key to success as management in general is more or less context related particularly in developing countries. The problem is how to make programme managers and the staff "research oriented". the key factors to me in building management capacity is to retained the staff. how can you build the capacity while you loose your staff. Our experience in Sudan showed that retention can be done through step-by-step in-service training (ie you offer short diploma, back to work for 2 years, then you offer master degree, back to work and build on....). What is good in in-service training is that you keep the post and you keep any incentive for the personnel while in-house training by definition detached the trainer from the programme till he/she completed the course. For further information about Sudan experience you can see the following article: 31. MALIK EM, ALI EM, MOHAMED TA, ELMURDI KA, ELFAKI AA, SAEED OK, ATTA A. Efforts to Control Malaria in Sudan - case study of the National Malaria Control Programme, 2001-2005. GIORNALE ITALIANO DI MEDICINA TROPICALE VOL. 11, N. 3-4, 2006
  • Reply to: President's Malaria Initiative (PMI): Country insecticide susceptibility summaries   1 week 6 days ago

    Thank you for the summary on biocide resistance in Africa. Clearly PMI is becoming a leader in the fight agsinst malaria, far outpacing the work done by WHO. However I am bothered by the PMI fixation on biocides, given that the anophelines are becoming resistant on such a widespread basis.

    Why don't you start supplementing the spraying with environmental methods? Or at least add larviciding with bti? It would seem the logical way to avoid collapse of the PMI effort in the near future, as happened with the Global program in the 1960's.

    Bill, still hoping