The research team from the Al Quds University has already shown that some plants from Palestine have a strong inhibitory effect on beta-hematin crystallisation. Salvia officinalis (M Akkawi et al., Malaria Journal, 2012, 11-Suppl,P3) and Artemisiasieberi from Palestine ( M Akkawi et al. Brit J Pharmacol Toxicol, accepted 2013). The therapeutic effect of quinine, chloroquine, amodiaquine is precisely based on hemozoin inhibition.
The science world is undergoing rapid changes, and so does the field of scientific publishing. The Lancet recently featured five articles on the current value and reduction of waste in biomedical research. An article in the Economist from a few months before titled 'How science goes wrong' is another eye-opener. Clearly, much is changing in the science world, and this includes us scientists working on malaria.
Here we are asking for your views regarding an issue we are discussing for the MalariaWorld Journal, entering its 5th volume this year: Should we continue with peer review, yes or no, or should we perhaps make it optional?
The diffusion of antimalarials into infected red blood cells has been studied by several authors. For example, three times more chloroquine accumulates in CQ sensitive strains than in the CQ resistant ones (KJ Saliba et al., Biochem Pharmacol. 1998, Aug 1 ;56, 313-20) Thediffusion of artemisinin into parasitized RBCs was found to be rapid, saturable, temperature dependent, irreversible. In contrast, simple passive diffusion of artemisinin was seen in nonparasitized RBCs.(N Vyas, Antimicro Ag Chemother, Jan 2002, 105-109).
Why are there two completely opposing views about the value of direct attacks on anopheline mosquito larvae or on adults, for suppressing malaria transmission ?
In recent public and written debates, I have seen diametrically and vehemently opposed views expressed on the value of attacking larvae through eliminating breeding sites, as opposed to the current emphasis on reducing biting by anopheline adults through bednets and indoor spraying.
"If you find Soper interesting, I really enjoyed the book by Prof Stepan, if you get a chance have a look" (Frank O. Richards).
Frank O. Richards has provided his slide deck, see attched file (5,7 MB).
MESA will post other great sessions on malaria elimination for you to listen to and download, watch this MalariaWorld page.
The polio vaccination was discovered in 1952, announced to world in 1955. A global effort to eradicate polio, led by the World Health Organization, UNICEF, and The Rotary Foundation, began in 1988. Using today, December 9, 2013 as a starting point, how long would it take to eradicate malaria worldwide?
Acoustic Larvicide is a technique where mosquito larvae are killed by rupturing their internal air bladders with acoustic energy. Their air bladders are resonant and therefore susceptible to acoustic energy in the octave from 18 kilohertz to 30 kilohertz. When sound at these frequencies with sufficient energy is put in the water the mosquito larvae instantly die.
This company, New Mountain Innovations appears to be the leader of this idea. Larvasonic.com
From 8-12 December, a conference titled 'Revisiting Malaria: Moving from Control to Sustainable Elimination' will be organised at the Hebrew University-Hadassah, Jerusalem, Israel.
The meeting conincides with the Centennial commemoration of the activities undertaken by Prof. Israel Kligler (picture, 2nd row, left), who was instrumental in eliminating malaria from Palestine. Malaria that in many ways was similar in intensity and impact as malaria seen in many parts of Africa today.
The meeting will be held in the form of a workshop and lectures, looking at past historical successes in malaria elimination, reviewing our current focus, and looking forward to identify what will be needed to move from control to sustainable elimination.
Also, workshop participants will work on scenario's for malaria elimination in island settings and ecological islands. The aim is to assist managers of NMCPs in moving forward in their country towards malaria elimination.
Participants have been selected from a variety of backgrounds that are considered essential in the planning and execution of operational malaria programmes.
Outputs from the meeting will be reported here on MalariaWorld, including a declaration by the participants.
The meeting is generously supported by the following organisations:
A recent paper (Anti-Plasmodial Polyvalent Interactions in Artemisia annua L. Aqueous Extract - Possible Synergistic and Resistance Mechanisms J J Suberu et al., PLoS ONE, November 2013 8 |11) opens the way for new antimalarial therapies. It provides answers to several questions which had not been addressed properly in the scientific literature. The paper studied the additive, synergistic or antagonistic effect of several constituants of Artemisia annua. It confirms clearly that the aqueous extract of Artemisia annua is three times as potent as pure artemisinin.
Sumitomo Chemical, Olyset Net maker, was accused of bribery.
The article “Cambodia investigates Sumitomo Chemical subsidiary in bribery case” was found in the Asahi .
Is this just the tip of iceberg?
On 6 November 2013, WHO/ PAHO honoured initiatives from three malaria-endemic countries with the ‘Malaria Champions of the Americas Awards’. The Malaria Champions of the Americas awards were given to Colombia (Colombia Malaria Project), the Dominican Republic (National Center for Control of Tropical Diseases), and Brazil (Secretariat of Health of the State of Acre). The Malaria Champions of the Americas was launched in 2008 to identify, celebrate and inspire excellence in efforts to fight the disease.
It is often asserted that there are two malaria vector interventions in widespread use: long-lasting insecticide treated bednets (LLIN) and indoor residual insecticide spraying (IRS). Are either of these vector interventions? I’ll argue that the answer is, “No!” What does this mean for the development of new methods?
Scientific Organizers: Pedro L. Alonso, Chetan E. Chitnis and Lee Hall
MalariaWorld is looking for authors to write columns about malaria - in the broadest sense. What we all read in scientific articles on malaria is only the tip of the iceberg when it gets to the world of malaria. Our malaria world is shaped by funding agencies, meeting outcomes, opinionated individuals and politics, but also you.
MalariaWorld as of today has 8102 registered members. We continuously check the validity of your email address to make sure that we remain connected with you, so you and 8101 other subscribers receive the MalariaWorld newsletter every single week of the year. This November we celebrated our fourth year of providing services to you. This was also a time to once more review our progress, including the progress we are making with the MalariaWorld Journal. The journal is now in its 4th volume and it is maturing, but we identified some real difficulties, one of which I want to bring to your attention here: manuscript reviewing...
The plasmodium parasite needs cholesterol for survival and multiplication. The replicative capacity of plasmodium liver forms is remarkable, achieving the fastest growth rates known.
We are very excited to be connecting with you through MalariaWorld. The Malaria Eradication Scientific Alliance – MESA - will feature the ever growing evidence base in malaria elimination, from science, to lessons learned, and policy.
In commemoration of Malaria Day in the Americas 2013
The Pan American Health Organization,
The Pan American Health and Education Foundation, and
The Center for Global Health at The George Washington University
Cordially invite you to attend the
Malaria in the Americas Forum 2013:
Haemolytic, hepatotoxic, cytotoxic, neurotoxic, cardiotoxic, genotoxic, ototoxic, embryotoxic, spleenotoxic, hemolytic, atherosclerosis, immunodepressive effects of chemical artemisinine derivatives (ACTs) at high doses.
Some recent research, mostly in relation with the resistance to ACT pills and/or artesunate injections, has highlighted serious secundary health effects at the doses prescribed by WHO.
Date: February 2-7, 2014
Location: Mérida, Yucatán, México
Scientific Organizers: Pedro L. Alonso, Chetan E. Chitnis and Lee Hall
Organized in collaboration with MESA – Malaria Eradication Scientific Alliance
Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. Click for the Program and more information .
Dr. Linda Veronica Venczel of Seattle has been appointed BIO Ventures for Global Healths new Director of Program and Partnership Management. Most recently Dr. Venczel was Senior Program Officer, Global Development at the Bill & Melinda Gates Foundation, Deputy Branch Chief for Polio Eradication at the Centers for Disease Control and Prevention in Atlanta, and International Advisor on Vaccines and Immunization for Bolivia at the Pan American Health Organization in Washington DC.
With the community, MESA monitors progress and takes the next steps to advance the science of malaria eradication. MESA reviews existing evidence and supports projects on research questions critical to malaria eradication. For more information, please visit www.mesamalaria.org.
Read MESA's latest posts here.
I am pleased to send you this brief summary of our most recent and interesting African Malaria Dialogue, held during a luncheon meeting on Wednesday 9 October at the Harvard School of Public Health in Boston.